지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 199 - 205 (7page)
이용수
초록· 키워드
오류제보하기
T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4＋ precursor cells. Since T-bet directly binds to the promoter of the IFN-γ gene and activates its transcription, T-bet deficiency impairs IFN-γ production in Th1 cells. Interestingly, T-bet-deficient Th cells also display substantially augmented the production of IL-2, a T cell growth factor. Exogenous expression of T-bet in T-bet deficient Th cells rescued the IFN-γ production and suppressed IL-2 expression. IFN-γ and IL-2 reciprocally regulate Th cell proliferation following TCR stimulation. Therefore, we examined the effect of T-bet on Th cell proliferation and found that T-bet deficiency significantly enhanced Th cell proliferation under non-skewing, Th1-skewing, and Th2-skewing conditions. By using IFN-γ-null mice to eliminate the anti-proliferative effect of IFN-γ, T-bet deficiency still enhanced Th cell proliferation under both Th1- and Th2-skewing conditions. Since the anti-proliferative activity of T-bet may be influenced by IL-2 suppression in Th cells, we examined whether T-bet modulates IL-2-independent cell proliferation in a non-T cell population. We demonstrated that T-bet expression induced by ecdysone treatment in human embryonic kidney (HEK) cells increased IFN-γ promoter activity in a dose dependent manner, and sustained T-bet expression considerably decreased cell proliferation in HEK cells. Although the molecular mechanisms underlying anti-proliferative activity of T-bet remain to be elucidated, T-bet may directly suppress cell proliferation in an IFN-γ- or an IL-2-independent manner.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Lazarevic, V. / 2013 / T-bet: a bridge between innate adaptive immunity / Nat. Rev. Immunol 13 : 777 ~ 789
[학술지(정기간행물)] - Hoyler, T. / 2013 / T-bet Gata3 in controlling type 1 type 2 immunity mediated by innate lymphoid cells / Curr. Opin. Immunol 25 : 139 ~ 147
[학술지(정기간행물)] - Miller, S. A. / 2010 / Molecular mechanisms by which T-bet regulates T-helper cell commitment / Immunol. Rev 238 : 233 ~ 246
[학술지(정기간행물)] - Chen, Z. / 2011 / FOXP3 RORgammat: transcriptional regulation of Treg Th17 / Int. Immunopharmacol 11 : 536 ~ 542
[학술지(정기간행물)] - Ziegler, S. F. / 2009 / FOXP3 the regulation of Treg/Th17 differentiation / Microbes. Infect 11 : 594 ~ 598
[학술지(정기간행물)] - Hoyler, T. / 2013 / T-bet Gata3 in controlling type 1 type 2 immunity mediated by innate lymphoid cells / Curr. Opin. Immunol 25 : 139 ~ 147
[학술지(정기간행물)] - Miller, S. A. / 2010 / Molecular mechanisms by which T-bet regulates T-helper cell commitment / Immunol. Rev 238 : 233 ~ 246
[학술지(정기간행물)] - Chen, Z. / 2011 / FOXP3 RORgammat: transcriptional regulation of Treg Th17 / Int. Immunopharmacol 11 : 536 ~ 542
[학술지(정기간행물)] - Ziegler, S. F. / 2009 / FOXP3 the regulation of Treg/Th17 differentiation / Microbes. Infect 11 : 594 ~ 598
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Tree Pollen Sensitization and Cross-Reaction of Children with Allergic Rhinitis or Asthma
고신대학교 의과대학 학술지
2019 .01
-
Species Specific Antiviral Activity of Porcine Interferon-α8 (IFNα8)
Immune Network
2017 .12
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
-
Clinical utility of balloon expulsion test for functional defecation disorders
Annals of Surgical Treatment and Research
2016 .01
-
Mucosal Immunity Related to CD8+ T Lymphocytes in Children with Helicobacter pylori Gastritis
Pediatric Gastroenterology, Hepatology & Nutrition
2024 .01
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research
2019 .01
-
이관 풍선 확장술 중 발생한 부정맥 2예: 기전과 치료
대한이비인후-두경부외과학회지
2023 .01
-
Moderate Exercise Enhances the Production of Interferon-γ and Interleukin-12 in Peripheral Blood Mononuclear Cells
Immune Network
2017 .06
-
Osteopontin Potentiates Pulmonary Inflammation and Fibrosis by Modulating IL-17/IFN-γ-secreting T-cell Ratios in Bleomycin-treated Mice
Immune Network
2015 .06
-
Innate Immunological Function of Bystander CD4 T Cells in Autoimmunity
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Post HCV Infection Due to MX Gene Stimulation Produced Post Treatment with Imported and Locally Produced Egyptian Biosimilar IFN
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
-
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Parasites, Hosts and Diseases
2016 .10
-
Effects of Interferon Beta in COVID-19 adult patients: Systematic Review
Infection and Chemotherapy
2021 .01
-
Interferon-driven Metabolic Reprogramming and Tumor Microenvironment Remodeling
Immune Network
2025 .02
-
The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms
Blood Research
2021 .01
-
The clinical role of interferon alpha in Philadelphia-negative myeloproliferative neoplasms
Blood Research
2021 .04
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells : Their Effects on Host Cell Proliferation and Cell Cycle Changes
Parasites, Hosts and Diseases
2016 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-511-001834863