지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
생리학 기반 약물동태(PBPK, Physiologically Based Pharmacokinetic) 모델링을 이용한 소아 약물 동태 예측 연구
Application of Physiologically Based Pharmacokinetic (PBPK) Modeling in Prediction of Pediatric Pharmacokinetics
이용수
생리학 기반 약물동태(PBPK, Physiologically Based Pharmacokinetic) 모델링을 이용한 소아 약물 동태 예측 연구
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In recent years, physiologically based pharmacokinetic (PBPK) modeling has been widely used in pharmaceutical industries as well as regulatory health authorities for drug discovery and development. Several application areas of PBPK have been introduced so far including drug-drug interaction prediction, transporter-mediated interaction prediction, and pediatric PK prediction. The purpose of this review is to introduce PBPK and illustrates one of its application areas, particularly pediatric PK prediction by utilizing existing adult PK data and in vitro data. The evaluation of the initial PBPK for adult was done by comparing with experimental PK profiles and the scaling from adult to pediatric was conducted using age-related changes in size such as tissue compartments, and protein binding etc. Sotalol and lorazepam were selected in this review as model drugs for this purpose and were re-evaluated using the PBPK models by GastroPlus$^{(R)}$. The challenges and strategies of PBPK models using adult PK data as well as appropriate in vitro assay data for extrapolating pediatric PK at various ages were also discussed in this paper.
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참고문헌 (27)
참고문헌 신청
Teorell, T / 1937 / Kinetics of distribution of substances administered to the body I : The extravascular modes of administration / Arch. Int. Pharmacodyn. Ther 57:205
Malcolm, R / 2011 / Physiologically-based pharmacokinetics in drug development and regulatory science / Annu. Rev. Pharmacol. Toxicol 51:45
Hannah, M. J / 2012 / Application of PBPK modelling in drug discovery and development at Pfizer / Xenobiotica 42:94
Jones, H / 2015 / Physiologically based pharmacokinetic modelling in drug discovery and development : A pharmaceutical industry perspective / Clin. Pharmacol. Ther 97:3
Jones, H / 2013 / Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development / CPT Pharmacometrics Syst. Pharmacol 2:e63
Malcolm, R / 2011 / Physiologically-based pharmacokinetics in drug development and regulatory science / Annu. Rev. Pharmacol. Toxicol 51:45
Hannah, M. J / 2012 / Application of PBPK modelling in drug discovery and development at Pfizer / Xenobiotica 42:94
Jones, H / 2015 / Physiologically based pharmacokinetic modelling in drug discovery and development : A pharmaceutical industry perspective / Clin. Pharmacol. Ther 97:3
Jones, H / 2013 / Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development / CPT Pharmacometrics Syst. Pharmacol 2:e63
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