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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Cordyceps militaris has shown to have various pharmacological activities including an immune-modulatory effect. Previously, we reported that anti-influenza effect of C. militaris in DBA/2 mice was mediated by increased IL-12 and the activation of NK cells. In this study, we investigated the effect of C. militaris on adaptive immune responses using DBA2 mice immunized with influenza vaccine. To determine the effect of C. militaris on antigen presentation capability, we treated RAW 264.7 cells with various concentrations of ethanol extract of C. militaris, which showed a significant upregulation of CD86 (B7.2), CD284 (TLR4), CD40, H-2k (MHC I) and I-Ad (MHC II). To examine the direct effect of C. militaris on adaptive immune responses, we immunized DBA2 mice with influenza vaccine in presence or absence of C. militaris. After 2 or 4 weeks, influenza-specific T cell proliferation, HAI titers and IFN-${\gamma}$ production were measured in plasma or PBMCs isolated from animals. Influenza-specific T cell proliferation and HAI titers were not considerably increased in immunized mice in presence of C. militaris. However, the production of IFN-${\gamma}$ was much greater in immunized mice with C. militaris as adjuvant than only immunized mice.
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참고문헌 (10)
참고문헌 신청
Tuli, H. S / 2013 / Cordycepin: a bioactive metabolite with therapeutic potential / Life Sci 93:863
Yue, K / 2013 / The genus Cordyceps: a chemical and pharmacological review / J. Pharm. Pharmacol 65:474
Zhou, X / 2009 / Cordyceps fungi : natural products, pharmacological functions and developmental products / J. Pharm. Pharmacol 61:279
신슬미 / 2010 / Immunostimulatory Effects of Cordyceps militaris on Macrophages by the Enhanced Production of Cytokines through the Activation of NF-κB / Immune Network 10(2):55~63
Chen, J. R / 1993 / The effects of Chinese herbs on improving survival and inhibiting anti-ds DNA antibody production in lupus mice / Am. J. Chin. Med 21:257
Yue, K / 2013 / The genus Cordyceps: a chemical and pharmacological review / J. Pharm. Pharmacol 65:474
Zhou, X / 2009 / Cordyceps fungi : natural products, pharmacological functions and developmental products / J. Pharm. Pharmacol 61:279
신슬미 / 2010 / Immunostimulatory Effects of Cordyceps militaris on Macrophages by the Enhanced Production of Cytokines through the Activation of NF-κB / Immune Network 10(2):55~63
Chen, J. R / 1993 / The effects of Chinese herbs on improving survival and inhibiting anti-ds DNA antibody production in lupus mice / Am. J. Chin. Med 21:257
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