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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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We investigated whether three flavonoids including daidzein, baicalein, hesperidin and ursolic acid, a triterpene acid, affect proliferation of MCF-7 human breast cancer cells stimulated by estrogenic compounds. Ursolic acid and baicalein inhibited proliferation of MCF-7 cells induced by PhIP, a food-derived carcinogen with estrogenic activity. Daidzein and hesperidin inhibited estradiol-induced proliferation of MCF-7 cells. These compounds should be further investigated for the possible involvement in signaling pathway after estrogen receptor binding in breast cancer cells.
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참고문헌 (22)
참고문헌 신청
Munoz, M / 2008 / Evaluation of international treatment guidelines and prognostic tests for the treatment of early breast cancer / Cancer Treat. Rev 34(8):701
Long, B. J / 2000 / Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer / Cancer Res 60(23):6630
Lauber, S. N / 2004 / The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo 4,5-b pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity / Carcinogenesis 25(12):2509
Lauber, S. N / 2007 / The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo 4,5-b pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer / Cancer Res 67(19):9597
Choi, E. J / 2007 / Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21 / Nutr. Cancer 59(1):115
Long, B. J / 2000 / Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer / Cancer Res 60(23):6630
Lauber, S. N / 2004 / The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo 4,5-b pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity / Carcinogenesis 25(12):2509
Lauber, S. N / 2007 / The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo 4,5-b pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer / Cancer Res 67(19):9597
Choi, E. J / 2007 / Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21 / Nutr. Cancer 59(1):115
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