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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2001.1
- 수록면
- 113 - 113 (1page)
이용수
이 논문의 연구 히스토리 (4)
2001
Study of resveratrol and its derivatives on the regulation of gene expression in MCF-7 cells transfected with either pERE-Luc or phCYP1A1-Luc
Joung
,
Ki-Eun
,
Kim
외 3명
대한약학회 학술대회
2001.01
학술대회자료
ESTABLISHMENT OF BIOASSAY TO DETECT ESTROGENIC FLAVONOIDS USING STABLE MCF-7-ERE CELL AND MCF-7 CELL PROLIFERASTION ASSAY
Joung
,
Ki-Eun
,
Kim
외 3명
한국응용약물학회 추계학술발표논문집
2001.01
학술대회자료
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초록· 키워드
오류제보하기
Stable MCF-7-ERE cells, in which pERE-Luc reporter gene has been stably integrated into the genome of the MCF-7 cells, were used to detect the estrogenic activity of various dietary flavonoids in either pure chemical or mixtures. Estradiol (E2) induced luciferase activity in dose dependent manner and this activity was inhibited by tamoxifen (Tam) concomitant treatment. A large series of flavonoids showed estrogenic activities, corresponding to EC5O values between 0.2 and 9 microM and their mixtures didn't show additive or synergistic effects. And we could find some structure and activity relationship. First, 4-methoxylation and catechol structure decreased estrogenic activities. Second, hydroxylation of 3 position reduced estrogenic effect. Third glycosides of flavonoids showed weak estrogenic activity or no activity. Interestingly, when tested at high concentrations, genistein, kaempferol, biochanin A and chrysin elicited luciferase induction higher than that of the maximum induction by estradiol. And these effects of genistein and kaempferol could not be fully inhibited with tamoxifen
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Establishment of bioassay to detect estrogenic flavonoids using stable MCF-7-EFE cell and MCF-7 cell proliferation assay
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Structure and estrogenic activity relationship of flavonoids using ERE-Luc Reporter and E-screening assay
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Assessment of the Estrogenicity of Isoflavonoids, Using MCF-7-ERE-Luc Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
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Biphasic Effects of Kaempferol on the Estrogenicity in Human Breast Cancer Cells
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Estrogenic activities of river waters of Korea in human
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Molecular Effects of Genistein on Proliferation and Apoptosis of MCF-7 Cell Line
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에스트로겐성 물질에 의해 자극된 인간 유방암 세포 증식에 대한 다이드제인, 바이칼레인, 헤스페리딘 및 우르솔산의 억제 효과
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STUDY OF RESVERATROL AND ITS DERIVATIVES ON THE REGULATION OG GENE EXPRESSION IN MCF-7 CELLS TRANSFECTED WITH EITHER pERE-LUC OR phCYP1A1-LUC
한국응용약물학회 추계학술발표논문집
2001 .01
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In vitro study on the estrogenic-like activities of bisphenol-A substitutes using reporter gene assay systems
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Identification of Estrogenic and Antiestrogenic Activities of Respirable Diesel Exhaust Particles by Bioassay-directed Fractionation
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Establishment of In Vitro Test System for the Evaluation of the Estrogenic Activities of Natural Products
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Evaluation of estrogenic activities of several pyrethroid insecticides in human breast cancer cell line
대한약학회 학술대회
2000 .01
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The estrogenic effects of pyrethroid insecticides using glucose-6-phosphate dehydrogenase in MCF-7 cells and uterine glutathione peroxidase in rats
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2001 .01
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Estrogenic Activity, and Developmental Toxicity Studies of Pyrethroid Insecticides
환경독성보건학회 심포지엄 및 학술대회
2003 .10
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Estrogenic activity of zinc pyrithione: an in vivo and in vitro study
Environmental Analysis Health and Toxicology
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Ecological risk assessment of estrogenic effects of bisphenol A on fish in Korea
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