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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Diethylstilbestrol (DESB) is a synthetic estrogen not only that routinely prescribed, but also that known to be a teratogen. In this study, we found a novel pharmacological feature that DESB is able to positively modulate CD29 $({\beta}1-integrin)$ function. Thus, DESB up-regulated homotypic cell-cell adhesion of monocytic U937 cells mediated by CD29. However, DESB did not increase the surface level of CD29 and its binding activity to ligand (fibronectin), according to flow cytometric analysis and cell-fibronectin adhesion assay. Instead, the DESB-mediated up-regulation of cell-cell adhesion was blocked by several signaling enzyme inhibitors. Treatment of U0126 [an extracellular signal-regulated kinase (ERK) inhibitor], SB20358 (a p38 inhibitor) or Rp-8-pCPT-cGMP (a protein kinase G inhibitor) clearly inhibited DESB-mediated up-regulation of cell-cell adhesion induced by CD29. However, estrogen receptor antagonist ICI 182,780 failed to abrogate DESB effect. Therefore, our data suggest that DESB may up-regulate CD29-mediated cell-cell adhesion via modulating intracellular signaling enzymes such as ERK, PKG, and p38, independent of estrogen receptor function.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Mittendorf, R / 1995 / Teratogen update: carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero / Teratology 51:435
Zelenka, P. S. / 2004 / Regulation of cell adhesion and migration in lens development / Int. J. Dev. Biol 48:857
Friedl, P. / 2004 / Collective cell migration in morphogenesis and cancer / Int. J. Dev. Biol 48:441
Bazan-Socha, S. / 2005 / Integrins in pulmonary inflammatory diseases / Curr. Pharm. Des 11:893
Schatzmann, F. / 2003 / Integrin signaling and mammary cell function / J. Mammary Gland Biol. Neoplasia 8:395
Zelenka, P. S. / 2004 / Regulation of cell adhesion and migration in lens development / Int. J. Dev. Biol 48:857
Friedl, P. / 2004 / Collective cell migration in morphogenesis and cancer / Int. J. Dev. Biol 48:441
Bazan-Socha, S. / 2005 / Integrins in pulmonary inflammatory diseases / Curr. Pharm. Des 11:893
Schatzmann, F. / 2003 / Integrin signaling and mammary cell function / J. Mammary Gland Biol. Neoplasia 8:395
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