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논문 기본 정보

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학술저널
저자정보
Han, Mi-Jin (Laboratory of Pharmacology, College of Pharmacy [BK21 Project] and Research Institute for Drug Development, Pusan National University) Lim, Sung-Mee (Department of Food Science & Technology, Tongmyong University) Kim, Yu-Lee (Laboratory of Pharmacology, College of Pharmacy [BK21 Project] and Research Institute for Drug Development, Pusan National University) Kim, Hyo-Lim (Laboratory of Pharmacology, College of Pharmacy [BK21 Project] and Research Institute for Drug Development, Pusan National University) Kim, Kye-Ok (Laboratory of Pharmacology, College of Pharmacy [BK21 Project] and Research Institute for Drug Development, Pusan National University) Sacket, Santosh J. (Laboratory of Pharmacology, College of Pharmacy [BK21 Project] and Research Institute for Drug Development, Pusan National University) Jo, Ji-Yeong (Laboratory of Pharmacology, College of Pharmacy [BK21 Project] and Research Institute for Drug Development, Pusan National University) Bae, Yoe-Sik (Department of Biochemistry, College of Medicine, Dong-A University) Okajima, Fumikazu (Laboratory of Signal Transduction, Institute for Mo) Im, Dong-Soon
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제16권 제4호
발행연도
2008.1
수록면
410 - 415 (6page)

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Previously, we identified albumin as an inhibitory factor in serum for cell adhesion of T cells such as human Jurkat T and primary cultured human T cells. In the present study, we found that other hematopoietic cell lines including U-937 human monocytes, THP-1 human monocytes, K-562 promyelocytic leukemia cells, and HL-60 human leukemia cells, also adhere to tissue culture flasks when serum is withdrawn, and albumin exerts an inhibitory effect on cell adhesion by those cells, implying that this inhibition is a common phenomenon in hematopoietic cells. Furthermore, we found that cell adhesion is inhibited by antioxidants such as (-)-epigallocatechin- 3-gallate (EGCG), morin, and a-tocopherol. Our results suggest that albumin may inhibit basal cell adhesion of hematopoietic cells and that the oxidative balance in the plasma may be important for cell adhesion of hematopoietic cells in vivo.

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