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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 376 - 382 (7page)
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Allergic diseases have rapidly increased in recent years. Mast cells play a critical role in IgE-mediated allergy responses and, therefore, closely associated with rhinitis, asthma, and atopic dermatitis. We studied anti-allergic effect of Penthorum chinense extract (PCE) in vitro and in vivo. PCE inhibited the degranulation of mast cells by antigen stimulation and its effect was dose-dependent and reversible in mast cells. PCE also suppressed the production of inflammatory cytokines such as TNF-${\alpha}$ and IL-4 by antigen in mast cells. Mechanistically, PCE inhibited the activation of Syk/LAT pathway which is a key signaling pathway for the activation of mast cells by antigen. Notably, PCE suppressed IgE-mediated allergic responses by antigen in mice. These results strongly suggest that PCE is a potential candidate for anti-allergic treatment.
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참고문헌 (18)
참고문헌 신청
Holgate, S.T. / 2008 / Treatment strategies for allergy and asthma / Nat. Rev. Immunol 8:218~230
Siraganian RP / 2002 / Protein tyrosine kinase Syk in mast cell signaling / Mol Immunol 38:1229~1233
Beaven MA / 2009 / Our perception of the mast cell from Paul Ehrlich to now / Eur J Immunol 39:11~25
안강모 / 2004 / 비만세포의 알레르기 연증 반응과 Innate Immunity에서의역할 / Korean Journal of Pediatrics 47(11):1137~1141
Xiao W / 2005 / Positive and Negative Regulation of Mast Cell Activation by Lyn via the FcεRI / J Immunol 175:6885~6892
Siraganian RP / 2002 / Protein tyrosine kinase Syk in mast cell signaling / Mol Immunol 38:1229~1233
Beaven MA / 2009 / Our perception of the mast cell from Paul Ehrlich to now / Eur J Immunol 39:11~25
안강모 / 2004 / 비만세포의 알레르기 연증 반응과 Innate Immunity에서의역할 / Korean Journal of Pediatrics 47(11):1137~1141
Xiao W / 2005 / Positive and Negative Regulation of Mast Cell Activation by Lyn via the FcεRI / J Immunol 175:6885~6892
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