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논문 기본 정보

자료유형
학술저널
저자정보
Perleidulam Bunddulam (Kitami Institute of Technology) Mizuki Nakamura (Kitami Institute of Technology) Anuu Zorig (Kitami Institute of Technology) Yu Hinata (Laboratory of Seeds Discovery and Development) Mikako Takasugi (Kyushu Sangyo University) Chao-Hui Feng (Kitami Institute of Technology) Toshitsugu Sato (Kitami Institute of Technology) Hirofumi Arai (Kitami Institute of Technology)
저널정보
한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.30 No.1
발행연도
2025.2
수록면
68 - 80 (13page)

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Astragalus membranaceus is a perennial plant belonging to the Fabaceae family that is widely distributed across northern Asia. A. membranaceus roots have been used as a traditional medicinal herb because of their numerous health benefits. However, the physiological properties of A. membranaceus leaves remain unknown. During allergic reactions, chemical mediators are released from mast cells, which trigger immediate hypersensitivity and subsequent macrophage-mediated inflammation. In the present study, we investigated the inhibitory effects of A. membranaceus leaf extract (AMLE) on allergic and inflammatory responses in immune cell lines. The results showed that AMLE suppressed the release of histamine and leukotriene B₄ from stimulated mast cells during allergic response by inhibiting the influx of calcium ions and down-regulating the expression of 5-lipoxygenase. Moreover, AMLE suppressed the release of nitric oxide, prostaglandin E₂, and cytokines from stimulated macrophages during inflammatory response. These effects were attributed to the suppression of mRNA and protein expressions of inducible nitric oxide synthase and microsomal prostaglandin E synthase-1 and the inhibition of the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells. Compared with the A. membranaceus root extract, AMLE had more potent inhibitory effects. Quercetin and kaempferol, the predominant polyphenolic compounds present in AMLE, suppressed the release of chemical mediators during allergic and inflammatory responses in immune cells. These results suggest that A. membranaceus leaves have a therapeutic potential for alleviating allergic inflammation and that polyphenols are the primary bioactive constituents of A. membranaceus leaves.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

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