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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Seung-Hoon (College of Pharmacy, Kyung Hee University) Shin, Yong-Wook (College of Pharmacy, Kyung Hee University) Bae, Eun-Ah (College of Pharmacy, Kyung Hee University) Lee, Bo-Mi (College of Pharmacy, Kyung Hee University) Min, Sung-Won (College of Pharmacy, Kyung Hee University) Baek, Nam-In (Graduate School of Biotechnology and PMRC, Kyung Hee University) Chung, Hae-Gon (Ganghwa Agricultural R&D Center) Kim, Nam-Jae (Institue of East and West Medical Research, Kyung Hee University) Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제29권 제9호
발행연도
2006.1
수록면
752 - 756 (5page)

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Artemisia princeps Pampanini, which is called Ssajuarissuk in Korean (SS-1), was fermented with lactic acid bacteria (LAB) and their passive cutaneous anaphylaxis reaction-inhibitory activity was investigated. Of these fermented agents, SS-1 extract fermented with Bifidobacterium infantis K-525 (F-SS-1) most effectively inhibited the release of ${\beta}$-hexosamindase from RBL-2H3 cells induced IgE. In IgE-induced RBL-2H3 cells, F-SS-1 inhibited proinflammatory cytokines IL-6 and $TNF-{\alpha}$ mRNA expression. Oral administration of SS-1 and F-SS-1 to mice inhibited passive cutaneous anaphylaxis (PCA) reaction induced by IgE and scratching behaviors induced by compound 48/80. The inhibitory activity of F-SS-1 against scratching behaviors was more effective than that of SS-1. These findings suggest that the fermentation of SS-1 with LAB can increase its antiallergic activity.

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