Inhibition of Dermatitis Development by Sopungsan in Nc/Nga Mice

Yuba Raj Pokharel; Sung Chul Lim; Sang Chan Kim; Hoo Kyun Choi; Keon Wook Kang

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질문

자료유형: 학술저널

저자정보: Yuba Raj Pokharel Sung Chul Lim Sang Chan Kim Hoo Kyun Choi Keon Wook Kang

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.24 No.1

발행연도: 2008.3

수록면: 17 - 22 (6page)

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연구주제

📖

연구배경

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연구방법

🏆

연구결과

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Sopungsan (SS) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study is to confirm whether or not SS has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SS was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SS inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of key steps in the signaling pathways mediating induction of TARC. In this study, SS selectively suppressed NF-κB activation which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SS on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SS.

#Atopic dermatitis #Anti-dermatitic activity #NF-κB #Sopungsan #TARC

참고문헌 (15)

참고문헌 신청

Berin, M.C / 2001 / Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts / Am. J. Resp. Cell. Mol. Biol 24:382~389

Furukawa, H / 2004 / Effect of an antiallergic drug (Olopatadine hydrochloride) on TARC/CCL17 and MDC/CCL22 production by PBMCs from patients with atopic dermatitis / J. Dermat. Sci 36:165~172

Hanifin, J / 1980 / Diagnostic features of atopic dermatitis / Acta. Dermato-Venereologica 92:44~47

Imai, T / 1997 / The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 / J. Biol. Chem

Kawasaki, S / 2001 / Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice / J. Immunol 166:2055~2062

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