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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Jong-Hoon (Department of Veterinary Physiology, College of Veterinary Medicine, Chonbuk, National University) Kang, Moon-Kyu (Purimed R&D Institute, Kyung-Hee University) Cho, Chong-Woon (Purimed R&D Institute, Kyung-Hee University) Chung, Hwan-Suck (Purimed R&D Institute, Kyung-Hee University) Kang, Chang-Woon (Department of Veterinary Physiology, College of Veterinary Medicine, Chonbuk, National University) Parvez, Shoukat (Purimed R&D Institute, Kyung-Hee University,NIBGE) Bae, Hyun-Su (Department of Physiology, College of Oriental Medicine, Kyung-Hee University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제29권 제9호
발행연도
2006.1
수록면
777 - 785 (9page)

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Nelumbinis Semen (NS), or lotus seed, is one of the most well-known traditional herbal medicines and is frequently used to treat cardiovascular symptoms in Korea. The anti-ischemic effects of NS on ischemia-induced isolated rat heart were investigated through analyses of changes in blood pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups: a control, untreated ischemia-induced group, and an ischemia-induced group treated with NS. There were no significant differences in perfusion pressure, aortic flow, coronary flow and cardiac output between the groups before ischemia was induced. The supply of oxygen and buffer was stopped for ten minutes to induce ischemia in isolated rat hearts, and NS was administered during ischemia induction. NS treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow and cardiac output under ischemic conditions (p<0.01). In addition, the mechanism of the anti-ischemic effects of NS was also examined through quantitation of intracellular calcium content in rat neonatal cardiomyocytes. NS significantly prevented intracellular calcium increases induced by isoproterenol (p<0.01). These results suggest that NS has distinct anti-ischemic effects through calcium antagonism.

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