지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 268 - 277 (10page)
이용수
초록· 키워드
오류제보하기
Ginsenosides are among the most well-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in South Korea. The anti-ischemic effects of compound K (CK), a metabolite of ginsenoside Rb1, on ischemia-induced isolated rat hearts were investigated through the analyses of the changes in the hemodynamics (blood pressure, aortic flow, coronary flow, and cardiac output) and the measurement of the infarct region. The subjects in this study were divided into four groups: the normal control, the CK-alone group, the ischemia-induced group without any treatment, and the ischemia-induced group treated with CK. No significant differences in perfusion pressure, aortic flow, coronary flow, and cardiac output were found between the groups before ischemia was induced. The oxygen and buffer supply was stopped for 30 min to induce ischemia 60 min after reperfusion in the isolated rat hearts, and the CK was administered 5 min before ischemia induction. The CK treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions. In addition, the hemodynamics (except for the heart rate) of the group treated with CK significantly recovered 60 min after reperfusion, unlike in the control group. CK significantly limited the infarct. These results suggest that CK treatment has distinct anti-ischemic effects in an exvivo model of an ischemia-reperfusion-induced rat heart.
목차
Abstract
INTRODUCTION
METERIAL AND METHODS
RESULTS AND DISSCUSSION
CONCLUSIONS
REFERENCES
참고문헌 (38)
참고문헌 신청
1. [단행본] - Sohn ES / 1980 / The effect of ginseng on blood pressure in spontaneous hypertensive rat and essential hypertension. Proceedings of the 3rd International Ginseng Symposium / Korean Gin Res Institute : 1 ~ 3
2. [학술지(정기간행물)] - Kim ND / 1994 / Ginsenosides evoke endothelium- dependent vascular relaxation in rat aorta / Gen Pharmacol. 25 : 1071 ~ 1077
3. [학술지(정기간행물)] - Shibata S / 1966 / Chemial studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins / Chem Pharm Bull. 14 : 595 ~ 600
4. [학술지(정기간행물)] - Toda N / 2001 / Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries / J Ethnopharmacol. 76 : 109 ~ 113
5. [학술지(정기간행물)] - Kim ND / 1999a / The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aorti rings:role of K+ channels / Eur J Pharmacol. 367 : 51 ~ 57
2. [학술지(정기간행물)] - Kim ND / 1994 / Ginsenosides evoke endothelium- dependent vascular relaxation in rat aorta / Gen Pharmacol. 25 : 1071 ~ 1077
3. [학술지(정기간행물)] - Shibata S / 1966 / Chemial studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins / Chem Pharm Bull. 14 : 595 ~ 600
4. [학술지(정기간행물)] - Toda N / 2001 / Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries / J Ethnopharmacol. 76 : 109 ~ 113
5. [학술지(정기간행물)] - Kim ND / 1999a / The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aorti rings:role of K+ channels / Eur J Pharmacol. 367 : 51 ~ 57
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cardioprotective Effect of the Mixture of Ginsenoside Rg₃ and CK on Contractile Dysfunction of Ischemic Heart
Journal of Ginseng Research
2007 .03
-
Effects of Nelumbinis Semen on Contractile Dysfunction in Ischemic and Reperfused Rat Heart
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
Protective effects of ginsenoside-Re against cardiac ischemia in relation to TNF-α production and p38 MAPK activity
고려인삼학회 학술대회
2011 .04
-
백서 신경에서 관찰한 허혈-재관류 손상 후 양상과 회복
Annals of Rehabilitation Medicine
2003 .01
-
Effect of Ursodeoxycholic Acid on Ischemia/Reperfusion Injury in Isolated Rat Heart
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
Effect of Ursodeoxycholic Acid on Ischemia/Reperfusion Injury in Isolated Rat Heart
한국응용약물학회 추계학술발표논문집
1998 .01
-
Protective Effect of Compound K After Global Ischemia in Rat Heart
고려인삼학회 학술대회
2009 .12
-
Involvement of Cortical Damage in the Ischemia/Reperfusion-Induced Memory Impairment of Wistar Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
Effect of Preconditioning Ischemia on Endothelial Dysfunction Produced by Ischemia-Reperfusion in Rabbit Coronary Artery
대한생리학회지
1995 .01
-
The Effect of High Dose Melatonin on Cardiac Ischemia- reperfusion Injury
Yonsei Medical Journal
2008 .01
-
Ginsenosides Protect Cardiac Hypertrophy and Ischemia and Reperfusion Injury
고려인삼학회 학술대회
2010 .12
-
타우로우루소데옥시콜린산이 흰쥐의 적출심장에서 허혈 및 재관류 손상에 미치는 영향
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
-
Ischemia reperfusion injury of liver and development of an experimental platform
한국실험동물학회 학술발표대회 논문집
2020 .07
-
백서 말초신경의 허혈-재관류 손상 후 운동치료의 예방적 효과
Annals of Rehabilitation Medicine
2004 .01
-
허혈-재관류 손상 후 흰쥐 간세포 생존능의 평가
Annals of Surgical Treatment and Research
2007 .07
-
온열적용이 대퇴사두근의 허혈-재관류 후 SOD 발현에 미치는 영향
대한물리치료학회지(JKPT)
2003 .01
-
Imaging Myocardial Ischemia and Reperfusion Injury via Cy5.5-Annexin V
Nuclear medicine and molecular imaging : NMMI
2012 .01
-
Protective Roles of Ginseng Saponin in Cardiac Ischemia and Reperfusion Injury
Journal of Ginseng Research
2009 .12
-
The Role of Oxygen Free Radicals and Phospholipase $A_2$ in Ischemia-reperfusion Injury to the Liver
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1995 .01
-
Ginseng Saponin Protect the Cardiac Ischemia and Reperfusion injury
고려인삼학회 학술대회
2009 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-524-001705011