지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 67 - 71 (5page)
이용수
초록· 키워드
오류제보하기
The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS) against ischemic damage in gerbils administered oral EAKS (25, and 50 ㎎/㎏) once a day for 7 days before transient cerebral ischemia. In the 50 ㎎/㎏ EAKS-treated ischemia group, about 67% of neurons in the hippocampal CA1 region (CA1) survived after ischemia/reperfusion (I/R) based on cresyl violet staining. We observed that EAKS treatment significantly maintained brain-derived neurotrophic factor (BDNF) immunoreactivity in the ischemic CA1 region after I/R. In addition, protein levels of BDNF in the 50 ㎎/㎏ EAKS-treated ischemia group were much higher than those in the vehicle-treated ischemia group after I/R. These findings indicate that repeated supplementation of EAKS protects neurons from ischemic damage, such that BDNF is distinctively maintained in ischemic areas.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (20)
참고문헌 신청
Ahn HC / 2009 / Ischemia-related changes in naive and mutant forms of ubiquitin and neuroprotective effects of ubiquitin in the hippocampus following experimental transient ischemic damage / EXPERIMENTAL NEUROLOGY 220:120~132
Almeida RD / 2005 / Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways / Cell Death Differ 12(10):1329~1343
Choi JH / 2009 / Platycodin D and 2''-Oacetyl- polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus / Brain Res 1279:197~208
Choi JK / 2009 / Topical anti-inflammatory and antipruritic effects of Alpinia katsumadai extracts / JOURNAL OF DERMATOLOGICAL SCIENCE 53(1):81~84
Hyang Sook Chun / 2008 / Neuroprotective Effects of Several Korean Medicinal Plants Traditionally Used for Stroke Remedy / Journal of Medicinal Food 11(2):246~251
Almeida RD / 2005 / Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways / Cell Death Differ 12(10):1329~1343
Choi JH / 2009 / Platycodin D and 2''-Oacetyl- polygalacin D2 isolated from Platycodon grandiflorum protect ischemia/reperfusion injury in the gerbil hippocampus / Brain Res 1279:197~208
Choi JK / 2009 / Topical anti-inflammatory and antipruritic effects of Alpinia katsumadai extracts / JOURNAL OF DERMATOLOGICAL SCIENCE 53(1):81~84
Hyang Sook Chun / 2008 / Neuroprotective Effects of Several Korean Medicinal Plants Traditionally Used for Stroke Remedy / Journal of Medicinal Food 11(2):246~251
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2012-510-004225561