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논문 기본 정보

자료유형
학술저널
저자정보
Choo, Young-Kug (Biological Science Major, College of Natural Sciences, Wonkwang University) Choi, Hee-Gon (Biological Science Major, College of Natural Sciences, Wonkwang University) Kim, Jin-Kyung (College of Medicine, Pochon CHA University, Infertility of Medical Center, CHA General Hospital) Kwak, Dong-Hoon (Biological Science Major, College of Natural Sciences, Wonkwang University) Cho, Jung-Ran (Biological Science Major, College of Natural Sciences, Wonkwang University) Kim, Ji-Yeoun (Biological Science Major, College of Natural Sciences, Wonkwang University) Kim, Byung-Jin (Biological Science Major, College of Natural Sciences, Wonkwang University) Jung, Kyu-Yong (Department of Pharmacology, Wonkwang University School of Medicine) Choi, Bong-Kyu (Department of Pharmacology, Wonkwang University School of Medicine) Shin, Min-Kyo (Department of Herbalogy, College of Oriental Medicine, Wonkwang University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제25권 제2호
발행연도
2002.1
수록면
178 - 183 (6page)

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A high molecular ar weight water-soluble chitosan (WSC) with an average molecular weight of 300 kD and a deacethylation level of over 90% was produced using a simple multi-step-membrane separation process. It is known that WSC prevents obesity induced by a high-fat diet. Consequently, this study investigated whether or not WSC improved the ovarian dysfunction caused by obesity in mice. The mice were fed a high density protein and lipid diet for weeks, followed by the administration of WSC at 480 mg/kg body weight per day for 4 days. Thereafter, the changes in body weight, ovulation rate, in vivo and in vitro fertilization and emboryonic development were measured . WSC markedly reduced the body weight of obese mice fed with a high-fat diet, but not in mice fed with a normal diet. WSC had siginificant effects on the ovulation rate, both the in vivo and in vitro fertilization rates and embryonic development. These results indicate an improvement in the ovarian and oviduct dysfunction caused by obesity, and suggest an adjustment in the internal secretions and metabolic functions.

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