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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 151 - 160 (10page)
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초록· 키워드
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Red ginseng and its extracts have been used as traditional medicines and functional foods in countries worldwide. The aim of this study was to examine the bioavailability of pectin lyase-modified red ginseng extracts (GS-E3D), and the effects of GS-E3D on adipogenesis of 3T3-L1 adipocytes, as well as on metabolic disorders such as hyperglycemia, dyslipidemia, and fatty liver in high-fat diet fed obese C57BL/6 mice. Mice were divided into 5 groups: normal diet group, high fat diet-vehicle group, high fat diet + 0.1 g/kg GS-E3D (0.1-GS-E3D), high fat diet + 0.3 g/kg (0.3-GS-E3D), high fat diet + 1.0 g/kg (1.0-GS-E3D). Treatment of GS-E3D reduced differentiation of 3T3-L1 adipocytes with low cytotoxicity. In the animal model, compared to the high fat diet control, serum glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TG, and leptin level were reduced in treatment animals in a dose-dependent manner. In addition, we found that GS-E3D could decrease total hepatic lipid droplets. These results suggest that GS-E3D, as a dietary supplement, has beneficial effects on obesity and may have useful effects in health-care products.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - 이은주 / 2012 / Oral administration of fermented red ginseng suppressed ovalbumin-induced allergic responses in female BALB/c mice / PHYTOMEDICINE 19 (10) : 896 ~ 903
2. [학술지(정기간행물)] - Lu JM. / 2009 / Ginseng compounds : an update on their molecular mechanisms and medical applications / Curr Vasc Pharmacol 7 (3) : 293 ~ 302
3. [학술지(정기간행물)] - Hong SY / 2011 / Simultaneous enrichment of deglycosylated ginsenosides and monacolin K in red ginseng by fermentation with Monascus pilosus / Biosci Biotechnol Biochem 75 (8) : 1490 ~ 1495
4. [학술지(정기간행물)] - Shibata S. / 2001 / Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds / J Korean Med Sci 16 : S28 ~ S37
5. [학술지(정기간행물)] - 박광현 / 2011 / 인삼추출물의 랫트 비만세포 히스타민 유리 억제 효과 / 한국자원식물학회지 24 (1) : 98 ~ 104
2. [학술지(정기간행물)] - Lu JM. / 2009 / Ginseng compounds : an update on their molecular mechanisms and medical applications / Curr Vasc Pharmacol 7 (3) : 293 ~ 302
3. [학술지(정기간행물)] - Hong SY / 2011 / Simultaneous enrichment of deglycosylated ginsenosides and monacolin K in red ginseng by fermentation with Monascus pilosus / Biosci Biotechnol Biochem 75 (8) : 1490 ~ 1495
4. [학술지(정기간행물)] - Shibata S. / 2001 / Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds / J Korean Med Sci 16 : S28 ~ S37
5. [학술지(정기간행물)] - 박광현 / 2011 / 인삼추출물의 랫트 비만세포 히스타민 유리 억제 효과 / 한국자원식물학회지 24 (1) : 98 ~ 104
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UCI(KEPA) : I410-ECN-0101-2016-528-001001805