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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 221 - 226 (6page)
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To save researcher's animal room space, time and expense, we developed a standard protocol for production of diet induced obesity C57BL/6NCrjBgi mice. In this study, we evaluated general clinical signs, weekly body weight changes, weekly food intake, organ weights and glucose tolerance on male C57BL/6NCrjBgi mice fed high (D12451, Rodent Diet with 45 ㎉% fat, Research Diets Inc., New Brunswick, NJ; D-45 Group) and low (D12450B, Rodent Diet with 10 ㎉% fat; D-10 Group) fat diets for 16 weeks. The mean body weight of D-45 Group had significantly increased compared to D-10 Group as early as 1 week after initiation of diet. Food intake was not significantly different between two groups, but caloric intake and food efficiency ratio were significantly increased in D-45 Group. Absolute organ weights of spleen, liver, pancreas and kidneys in D-45 Group were significantly increased compared to D-10 Group. The significantly increased fat deposit in epididymal and perirenal area was found in D-45 Group. In glucose tolerance test, D-45 Group mice had glucose intolerance compared to D-10 Group mice. In summary, the first characterization data of C57BL/6NCrjBgi mice fed high fat diet for 16 weeks is very similar to the most frequently used C57BL/6J diet induced obesity (DIO) mouse model of Jackson Laboratory, USA.
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UCI(KEPA) : I410-ECN-0101-2009-510-016363057