지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제19권 제1호
- 발행연도
- 1996.1
- 수록면
- 62 - 65 (4page)
이용수
초록· 키워드
오류제보하기
A homologous series of twenty, hitherto unreported, analogues of 5-halosubstituted $1, 3-Bis(\omega-cyanoalkyl)uracil$acyclic nucleosides were synthesized by the series of alkylation reactions of 5-halouracils with the corresponding chloroacetonitrile, chloropropionitrile, chlorobutyronitrile and 5-chlorovaleronitrile $(Cl-(C_ 2)_n-CN: n=l, 2, 3, 4)\; in\; anhydrous\; DMSO\; (or DMF)/K_2CO_3(or NaH)\; under\; 75^{\circ}C$ temperature. Antitumor activities for the synthesized compounds were determined against three cell lines (FM-3A cell, P-388 cell and U-938 cell lines). The compounds that exhibited moderate activity to significant activity, included la-b, 2a-b, 3a-c, and 4a, whose compounds were active against P-388, FM-3A and U-937 cell lines with the compounds la, lb, and 2a, showing significant antitumor activity (inhibitory concentrations $(IC_{50})$ ranged from 2.2 to $7.0\mug/ml$). Their strucrure-activity relationship did not show any activity differences in their effective chain length (methyl, ethyl, propyl, butyl) in 1, 3-bis(.omega.-cyanoalkyl) uracils.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Synthesis and Evaluation of Antitumor Activity of a Homologous Series of $1-({\omega$}-Cyanoalkyl)-and $1,3-Bis({\omega}-cyanoalkyl)uracil$ Nucleoside Analogues
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1994 .01
-
5-Substituted Pyrimidine Acyclis Nucleoside Analogues 1-Cyanomethyl- and 1-(4-Cyanobutyl)-5-substituted Uracils as Candidate Antitumor Agents
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1994 .01
-
Synthesis and antitumor evaluation of $\alphamethylene-\gamma-butyrolactone-linked$ to 5-substituted uracil nucleic acid bases
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1996 .01
-
한약재 수치에 관한 연구 (Ⅶ)-천남성의 수치방법에 의한 uracil의 함량분석-
한국한의학연구원 논문집
2003 .12
-
Potential Antitumor ${\alpha}$-methylene-${\gamma}$-butyrolactone-bearing nucleic acid bases. 2. synthesis of $5^I-Methyl-5^I$-[2-(5-substituted uracil-1-yl)ethyl]-$2^I-oxo-3^I$-methylenetetrahydrofurans
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
Effects of pyrimidine salvage inhibitors on uracil incorporation of Toxoplasma gondii
Parasites, Hosts and Diseases
1990 .06
-
Synthesis and Antitumor Evaluation of cis-(1,2-Diaminoethane) dichloroplatinum (II) Complexes Linked to 5- and 6-Methyleneuracil and -uridine Analogues
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
A New Uracil Derivative and A New Acylglycosyl Sterol from Quisqualis Fructus
대한약학회 학술대회
2002 .01
-
A synthesis of novel acyclic nucleosides
대한약학회 학술대회
2002 .01
-
Synthesis and Antitumor Evaluation of Acyclic 1-[${\omega}$-(N^I-2-chloroethyl-N^I-nitrosoureido)alkyl]thymidine Nucleoside Analogues
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
2′-메칠 및 4′-페닐 측쇄를 가진 새로운 카보사이클릭 뉴크레오사이드의 합성 및 항바이러스 약효검색
약학회지
2004 .01
-
放射性 Bromouracil을 利用한 癌診斷에 關한 硏究 : 擔癌動物癌組織 및 各種臟器組織에 있어서의 Br82 分布에 關하여
Annals of Surgical Treatment and Research
1963 .11
-
Efficacy of Bispectral Index Monitoring for Midazolam and Meperidine Induced Sedation during Endoscopic Submucosal Dissection: A Prospective, Randomized Controlled Study
Gut and Liver
2011 .01
-
Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children
Clinical and Experimental Pediatrics
2019 .01
-
Use of the Bispectral Index to Predict Eye Position of Children during General Anesthesia
Korean Journal of Ophthalmology
2018 .01
-
${\omega}$-피리딜 알켄산의 형태와 활성간의 상관관계
약학회지
1997 .01
-
비-식이성 알레르기 유래 아토피성 개들에서의 소양증을 조절된 규정식 오메가-6:오메가-3 비율로 감소시키기(8)
대한수의사회지
1997 .01
-
Synthesis of Novel 2'-Methyl Carbovir Analogues as Potent Antiviral Agents
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Omega 3계열 불포화 지방산의 암세포주에 대한 성장 억제효과
약학회지
2008 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0