지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Conformational free energy calculations using an empirical potential function and a hydration shell model(program CONBIO) were carried out on hypoglycemic agent acetohexamide and tolazamide in the unhydrated and hydrated states. The initial geometry of sulfonylureas was obtained from X-ray crystallographieal data and homologous molecular fragments. In both states, the feasible conformations were obtained from the calculations of conformational energy, conformational entropy, and hydration free energy by varying all the torsion angles of the molecules. From the calculation results, it is known that the conformations] entropy is the major contribution to stabflize the low-free-energy conformations of two sulfonylureas in both states. But, in hydrated state, the hydration does not directly affect each conformations. The intramolecular hydrogen bonding of sulfonylurea hydrogen and 7-membered nitrogen appeared to the conformations of tolazamide in both states. It is thought that the hydrogen bonding decrease steric hindrance on the receptor binding direction. The substitution of alicyclic or N-heterocyclic ring than that of carbons chain of urea moiety may be properly interaction between sulfonylureas and the putative pancreatic receptor.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
술포닐 우레아 유도체들의 형태분석
약학회지
1992 .01
-
The Crystal and Molecular Structure of 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl) Urea: Tolazamide ($C_{14}H_{21}N_3O_3S$)
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1988 .01
-
소염진통성 페나메이트 유도체들의 형태분석
약학회지
1996 .01
-
Conformational Analysis of Some Antibacterial Agent 4-Aminodiphenyl Sulfones
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1990 .01
-
Benzenesulfonyl 유도체들의 구조와 Staphylococcus aureus에 대한 항균력
약학회지
1989 .01
-
Computer Graphics/Grid-Search 분석에 의한 Quinolone Conformation에 관한 이론적 연구
약학회지
1994 .01
-
Bioactive Conformation of Peptides for Drug Design
대한약학회 학술대회
2000 .01
-
Conformational Study of Cyclic Ac-Cys-Pro-Xaa-Cys-NHMe Peptides: a Model for Chain Reversal and Active Site of Disulfide Oxidoreductase
대한약학회 학술대회
2002 .01
-
Successful switching from insulin to sulfonylurea in a 3-month-old infant with diabetes due to p.G53D mutation in KCNJ11
Annals of Pediatirc Endocrinology & Metabolism
2018 .01
-
Crystal Structure of Tuguaconitine, A Diterpene Alkaloid from Aconitum sibiricum
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Multiple Conformations in the Ligand-Binding Site of the Yeast Nuclear Pore Targeting Domain of NUP116P
대한약학회 학술대회
2005 .01
-
Conformations and activities of linear RGDX tetrapeptides
대한약학회 학술대회
2000 .01
-
Isolation and Characterization of $\beta$-Galactoside Specific Lectin from Korean Mistletoe (Viscum album var. coloratum with Lactose-BSA-Sepharose 4B and Changes of Lectin Conformation
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1998 .01
-
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Conformation이 고정된 Sulfonylurea 유도체의 혈당상승작용
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1996 .01
-
Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Effective conformation of HIV NNRTI Trovirdine analogs
대한약학회 학술대회
2001 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0