지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 93 - 99 (7page)
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The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(${\alpha}2-3$) or sialyl(${\alpha}2-6$) linkage specificity of oligosaccharide moieties for avian or human virus, respectively. In the case of H5N1 and newly mutated flu viruses, classification based on the linkage type does not correlate with human infection and human-to-human transmission of these viruses. It is newly suggested that flu infection and transmission to humans require high affinity binding to the extended conformation with long length sialyl(${\alpha}2-6$)galactose containing oligosaccharides. On the other hand, the avian flu virus requires folded conformation with sialyl(${\alpha}2-3$) or short length sialyl(${\alpha}2-6$) containing trisaccharides. This suggests a potential future direction for the development of new species-specific antiviral drugs to prevent and treat pandemic flu.
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참고문헌 (69)
참고문헌 신청
Babu, Y. S / 2000 / BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orallyactive, and selective influenza neuraminidase inhibitor throughstructure-based drug design / J. Med. Chem 43:3482~3486
Bantia, S / 2001 / Comparisonof the anti-influenza virus activity of RWJ-270201 with thoseof oseltamivir and zanamivir / Antimicrob. Agents Chemother 45:1162~1167
Baz, M / 2009 / Emergence of oseltamivir-resistant pandemic H1N1virus during prophylaxis / N. Engl. J. Med 361:2296~2297
Bateman, A. C / 2010 / Glycan analysis and influenza A virus infectionof primary swine respiratory epithelial cells: the importanceof NeuAcα2-6 glycans / J. Biol. Chem 285:34016~34026
Belser, J. A / 2008 / Contemporary North Americaninfluenza H7 viruses possess human receptor specificity: Implicationsfor virus transmissibility / Proc. Natl. Acad. Sci 105:7558~7563
Bantia, S / 2001 / Comparisonof the anti-influenza virus activity of RWJ-270201 with thoseof oseltamivir and zanamivir / Antimicrob. Agents Chemother 45:1162~1167
Baz, M / 2009 / Emergence of oseltamivir-resistant pandemic H1N1virus during prophylaxis / N. Engl. J. Med 361:2296~2297
Bateman, A. C / 2010 / Glycan analysis and influenza A virus infectionof primary swine respiratory epithelial cells: the importanceof NeuAcα2-6 glycans / J. Biol. Chem 285:34016~34026
Belser, J. A / 2008 / Contemporary North Americaninfluenza H7 viruses possess human receptor specificity: Implicationsfor virus transmissibility / Proc. Natl. Acad. Sci 105:7558~7563
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