지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
To achieve a better understanding of antioxidant action manifested by malotilate, the dithiol malonates, we monitored the oxy radical-scavenging system against the chronic hepatic damage induced by $CCl_4$ alone or in combination with ethanol. Malotilate was given orally at a dose of 100 mg/kg/day and $CCl_4$ 1.5 ml/kg was injected subcutaneously twice a week for 4 weeks. In each group receiving ethanol, drinking water was replaced by 20% aqueous solution or glucose, isocaloric amounts of ethanol, as a control of ethanol was diluted in its drinking water. Each rat was killed as a starved state at 18 hours after the period of the experiment, four weeks. The results were summarized as follows: 1) Malotilate inhibited the rate of generation of superoxide radicals, the accumulation of lipoperoxides, and promoted the synthesis of glutathione in the liver. 2) Malotilate stimulated the enhancement of activity of superoxide dismutase in hepatic mitochondria. 3) Malotilate had no effects on the hepatic $H_2O_2$ contents. 4) Malotilate showed the increase of catalase activity in the liver poisoned with $CCl_4$, and also gave a tendency to increase it in the liver intoxicated with ethanol. Thus, our data suggested that the activation of hepatic antioxidant system in the presence of malotilate would play a role in protecting liver against the toxic effects of oxy radical and/or lipid peroxides under the hepatotoxic conditions induced by $CCl_4$ with or without ethanol. However, the effects of malotilate against the ethanol-induced hepatotoxicity appear to be insignificant.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
혈중 Ethanol 및 Acetaldehyde의 농도에 미치는 Malotilate의 영향
약학회지
1987 .01
-
Apoptosis of hippocampal neurons on Synergistic effect of amyloid β-peptide1-42 and ethanol
대한체질인류학회 학술대회 연제 초록
2006 .05
-
G009의 간 보호작용에 관한 연구
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
-
인진호탕가웅담(茵蔯蒿湯加熊膽)의 경구투여(經口投與)가 $CCl_4$ 투여(投與)로 유발(誘發)된 간경변(肝硬變)에 미치는 영향(影響)
대한한의학방제학회지
2001 .01
-
Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats
Journal of Ginseng Research
2017 .07
-
Inhibition of Ethanol Absorption by Rhodiola sachalinensis in Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1997 .01
-
급성 간손상의 실험동물 피부조직에 있어서 Oxygen Free Radical의 대사효소 활성 변동
대한의생명과학회지
1999 .06
-
Comparative Studies on the Therapeutic Effect and Withdrawal Reversing Phenomenon of GODEXⓇ in CCl₄-Liver Injury Model in Rats
한국실험동물학회 학술발표대회 논문집
2003 .06
-
Protective Effect of Anthocyanins against the Hepatotoxicity of Carbon Tetrachloride in Rats
Laboratory Animal Research
2008 .09
-
흰쥐에서 지구자 추출물의 에탄올 유도 숙취 행동 개선 효능
약학회지
2014 .01
-
Morin Protects Acute Liver Damage by Carbon Tetrachloride ($CCl_4$) in Rat
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
CCl₄에 의한 간손상 정도 차이에 따른 Xylene 대사 변동
Toxicological Research
1999 .09
-
흰쥐에서 민들레 추출물이 사염화탄소에 의한 산화적 스트레스의 경감기전
동의생리병리학회지
2010 .06
-
흰쥐에서 민들레 추출물이 사염화탄소에 의한 산화적 스트레스의 경감기전
동의생리병리학회지
2010 .01
-
AVM TREATMENT 시술에 100% PURE ETAHNOL 사용시 THROMBOSIS 형성시간에 관한 연구
대한인터벤션영상기술학회지
2016 .05
-
사염화탄소-유발지방간에 대한 L-글루탐산 일나트륨의 보호작용
약학회지
1992 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0