지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
This study was attempted to investigate the pharmacokinetics of cyclosporine (10mg/kg, oral) in rabbits with $CCI_4$ and bile duct ligation-induced hepatic disorder. The area under the curve (AUC) of blood cyclosporine concentration versus time was significantly increased ($CCI_4$-induced hepatic disorder. Elimination rate constant (Kel) was significantly decreased (p<0.05, p<0.01) in rabbits with $CCI_4$ and bile duct ligation-induced hepatic disorder. Volume of distribution (Vdss) and total body clearance (CLtot) were significantly decreased (p<0.01) in rabbits with $CCI_4$-induced hepatic disorder. But Vdss was significantly increased (p4-induced hepatic disorder were 874ng/ml and 2.71 hr, respectively. Cmax and Tmax values in rabbits with bile duct ligation were 105ng/ml and 2.834 hr, respectively. From results of this experiment. It is desirable to do therapeutic drug monitoring of cyclosporine for effective treatment when the cyclosporine is administered to patients with liver disorder m clinical practice.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
간장장애 가토에서 베라파밀의 약물동태
한국임상약학회지
2004 .01
-
가토 간내 선택적 담관결찰후 간부피의 변화에 대한 실험적 연구
대한방사선의학회지
1998 .01
-
The Effect of Nimodipine on the Pharmacokinetics of Cyclosporine in Rabbits
대한약학회 학술대회
2002 .01
-
Pharmacokinetics of Paclitaxel in Rabbits with Carbon Tetrachloride-Induced Hepatic Failure
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
實驗的 總輸膽管 部分結紮 家兎의 肝微細血管構築에 關한 硏究
Annals of Surgical Treatment and Research
1980 .01
-
가토에서 니모디핀과 싸이크로스포린과의 약물상호작용
약학회지
2002 .01
-
pharmacokinetics of paclitaxel in rabbits with carbon tetrachloride-induced hepatic failure
대한약학회 학술대회
2002 .01
-
조혈모세포 이식을 받은 소아 환자에서 cyclosporine의 집단 약동학 분석
한국임상약학회지
2018 .01
-
근위부 담도암에서 간절제술
Annals of Hepato-Biliary-Pancreatic Surgery
1997 .06
-
간외담도, 문맥 및 간동맥의 결찰로 인한 간세포 손상에 관한 실험적 연구
Annals of Surgical Treatment and Research
1989 .09
-
스테로이드 저항성 신증후군에서 cyclosporine 치료 반응 및 결과
Clinical and Experimental Pediatrics
2008 .01
-
Isolated aberrant right cysticohepatic duct injury during laparoscopic cholecystectomy: Evaluation and treatment challenges of a severe postoperative complication associated with an extremely rare anatomical variant
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .05
-
담관의 자연 천공
Journal of the Korean Association of Pediatric Surgeons : JKAPS
1996 .01
-
신장이식 환자에서 Cyclosporine의 적정 투여량
Annals of Surgical Treatment and Research
1994 .08
-
latrogenic bile duct injury associated with anomalies of the right hepatic sectional ducts
대한외과학회 학술대회 초록집
2010 .11
-
Comparison of PD and Bile Duct Resection for Middle Bile Duct Cancer
한국간담췌외과학회 학술대회지
2014 .04
-
Pharmacokinetics of Verapamil and Its Major Metabolite, Norverapamil from Oral Administration of Verapamil in Rabbits with Hepatic Failure Induced by Carbon Tetrachloride
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2005 .01
-
Clinical Outcomes of Cyclosporine Treatment for Noninfectious Uveitis
Korean Journal of Ophthalmology
2012 .01
-
Effects of Hwalgidan® on Hepatic Injury Induced by Carbon Tetrachloride in Rats
Laboratory Animal Research
2007 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0