지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The purpose of this study was to investigate the pharmacokinetic changes of veapamil in rabbits with hepatic disorder induced by carbon tetrachloride. The plasma concentrations of verapamil were increased significantly (p<0.05, in slight group; p<0.01, in moderate and severe group) in all groups of hepatic disorder compared to the control group. Morover, the Cmax in slight (77.9% increase), moderate (110% increase), and severe (174% increase) hepatic disorder groups were significantly (p<0.05, in slight; p< 0.01, in moderate and severe) higher than that in control rabbits. These resulted in significantly (p<0.05, in slight; p<0.01, in moderate and severe) greater area under the plasma concentration-time curve (AUC) in moderate (49.8% increase), moderate (95.0% increase), and severe (144% increase) hepatic disorder groups than that in control rabbits. Hence, the relative bioavailability values were 149, 195, and 244% for slight, moderate, and severe hepatic disorder groups, respectively. This could be due to decrease in metabolism of verapamil in the liver because of suppressed hepatic function in the hepatic disorder groups because verapamil is mainly metabolized in the liver.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Choi JS / 2002 / Pharmacokinetics of acebutolol and its main metabolite,diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepat
Choi JS / 2002 / Pharmacokinetics of paclitaxel in rabbits with carbon tetrachloride-induced hepatic failure 25 : 973 ~ 977
Eichelbaum M / 1979 / The metabolism of DL-[14C]verapamil in man 7 : 145 ~ 8
Fleckenstein A / 1977 / Specific pharmacology of calcium in myocardium,cardiac pacemakers,and vascular smooth muscle 17 : 149 ~ 66
Freedman SB / 1981 / Verapamil kinetics in normal subjects and patients with coronary artery spasm 30 : 644 ~ 52
Choi JS / 2002 / Pharmacokinetics of paclitaxel in rabbits with carbon tetrachloride-induced hepatic failure 25 : 973 ~ 977
Eichelbaum M / 1979 / The metabolism of DL-[14C]verapamil in man 7 : 145 ~ 8
Fleckenstein A / 1977 / Specific pharmacology of calcium in myocardium,cardiac pacemakers,and vascular smooth muscle 17 : 149 ~ 66
Freedman SB / 1981 / Verapamil kinetics in normal subjects and patients with coronary artery spasm 30 : 644 ~ 52
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