Effect of Uric Acid on the Development of Chronic Kidney Disease: The Korean Multi-Rural Communities Cohort Study

문광호; 유경임; 최보열; 김미경; 신민호; 신동훈

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자료유형: 학술저널

저자정보: 문광호 유경임 최보열 김미경 신민호 신동훈

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제51권 제5호

발행연도: 2018.1

수록면: 248 - 256 (9page)

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연구배경

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연구방법

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Objectives: Several studies have investigated the effects of serum uric acid (SUA) levels on chronic kidney disease (CKD), with discrepant results. The effect of SUA levels on CKD development was studied in the Korean rural population. Methods: A total of 9695 participants aged ≥40 years were recruited from 3 rural communities in Korea between 2005 and 2009. Of those participants, 5577 who participated in the follow-up and did not have cerebrovascular disease, myocardial infarction, cancer, or CKD at baseline were studied. The participants, of whom 2133 were men and 3444 were women, were grouped into 5 categories according to their quintile of SUA levels. An estimated glomerular filtration rate of <60 mL/min/1.73 m2 at the time of follow-up was considered to indicate newly developed CKD. The effects of SUA levels on CKD development after adjusting for potential confounders were assessed using Cox proportional hazard models. Results: Among the 5577 participants, 9.4 and 11.0% of men and women developed CKD. The hazard ratio (HR) of CKD was higher in the highest quintile of SUA levels than in the third quintile in men (adjusted HR, 1.60; 95% confidence interval [CI], 1.02 to 2.51) and women (adjusted HR, 1.56; 95% CI, 1.14 to 2.15). Furthermore, CKD development was also more common in the lowest quintile of SUA levels than in the third quintile in men (adjusted HR, 1.83; 95% CI, 1.15 to 2.90). The effect of SUA was consistent in younger, obese, and hypertensive men. Conclusions: Both high and low SUA levels were risk factors for CKD development in rural Korean men, while only high levels were a risk factor in their women counterparts.

참고문헌 (34)

참고문헌 신청

Couser WG / 2011 / The contribution of chronic kidney disease to the global burden of major noncommunicable diseases / Kidney Int 80(12):1258~1270

진동찬 / 2015 / Lessons from 30 years’ data of Korean end-stage renal disease registry, 1985–2015 / Kidney Research and Clinical Practice 34(3):132~139

박지인 / 2016 / Prevalence of Chronic Kidney Disease in Korea: the Korean National Health and Nutritional Examination Survey 2011-2013 / Journal of Korean Medical Science 31(6):915~923

Iseki K / 2004 / Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort / Am J Kidney Dis 44(4):642~650

Hakoda M / 2005 / Serum uric acid concentration as a risk factor for cardiovascular mortality: a longterm cohort study of atomic bomb survivors / J Rheumatol 32(5):906~912

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