지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.12
- 수록면
- 375 - 380 (6page)
이용수
초록· 키워드
오류제보하기
The toxicity of CKD-602 was investigated at doses of 0, 3, 9, and 27 mg/kg in rats, by administering the same total dose over 24-hr continuous infusion or bolus injection. CKD-602 treatment caused gastrointestinal symptoms such as diarrhea, soft stool, and soiled perineal region. It also decreased body weight at doses of 9 and 27 mg/kg in a dose-dependant manner. At 3 mg/kg, clinical signs and body weight decrease were more severe in the infusion group than in the bolus group. In the bolus group, mortalities were 0/8, 0/8, 1/8, and 3/8 at 0, 3, 9, and 27 mg/kg, respectively, whereas those were 0/8, 1/8, 8/8, and 8/8 in the infusion group. LD50 values were 36.25 mg/kg for bolus and 3.50 mg/kg for infusion, respectively. This finding indicates that the toxic potency of CKD-602 by continuous infusion is about 10 times higher than by bolus injection. Our findings suggest that the toxic effects of CKD-602 are dependant upon the duration of intravenous administration.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULT
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of Single-Dose Toxicity by Intravenous Infusion or Bolus Injection with CKD-602, a Camptothecin Anticancer Agent in Rats (II): Hematological and Serum Biochemical, and Histopathological Changes
Toxicological Research
2004 .12
-
신규 캄토테신계 항암제 CKD-602의 약물동태: 흡수
약학회지
1998 .01
-
Acute Toxicity of CKD-602, a New Anticancer Agent, in Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2004 .01
-
Toxicity Study of CKD-602, a Camptothecin Anticancer Agent: 5-Day Repeated Intravenous Administration in Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2004 .01
-
5-Day Repeated Intravenous Dose Toxicity Study of a New Camptothecin Anticancer Agent CKD-602 in Rats
Toxicological Research
2004 .03
-
신규 캄토테신계 항암제 CKD-602의 약물동태: 분포, 대사 및 배설
약학회지
1998 .01
-
변형 근치적 유방절제술 시행 환자의 방사선 치료 시 3D-bolus와 step-bolus의 비교 평가
대한방사선치료학회지
2016 .01
-
Absorption, Distribution, Metabolism, and Excretion of CKD-732, a Novel Antiangiogenic Fumagillin Derivative, in Rats, Mice, and Dogs
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
3D 프린터를 이용한 Customized Bolus 제작에 관한 연구
대한방사선치료학회지
2015 .01
-
구강암 세포주에 대한 CKD-602의 항암 효과
대한구강악안면외과학회지
2005 .01
-
Development of CKD-602, a novel camptothecin derivative, for anticancer agent
대한약학회 학술대회
2000 .01
-
Camptothecin계 항암제 CKD-602의 유전독성평가 ( Genotoxicity Studies of An Anticancer Agent of Camptothecin Series, CKD-602 )
한국환경성돌연변이·발암원학회지
1998 .09
-
Geometric Evaluation of Patient-Specific 3D Bolus from 3D Printed Mold and Casting Method for Radiation Therapy
의학물리
2019 .01
-
균일한 두피 방사선 치료를 위한 bolus 적용 방법: Sutured bolus
의생명과학
2019 .01
-
Bolus Injection 방법을 이용해서 측정한 정상 성인의 뇌척수액 배출저항
대한신경외과학회지
2000 .01
-
9 MeV 전자선 치료에서 표면선량 증가의 방법
대한방사선치료학회지
1989 .01
-
새로운 Anthracycline계 항암성 항생물질 DA-125의 랫드에 대한 4주 용량설정시험(DRF)과 13주 아급성 독성시험
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
-
Neck Node Bolus Technique in the Treatment of Nasopharyngeal Carcinoma with Intensity-modulated Radiotherapy
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Higher Risk for All-cause Mortality of Staphylococcus aureus Bacteremia in Patients with Non-Dialysis Dependent Chronic Kidney Disease
Infection and Chemotherapy
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-015230767