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The Role of Insulin-like Growth Factor I(IGF-I), and IGF Binding Protein (IGFBP) in Mouse Lung Cancer Cells
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마우스 폐암 세포에서 Insulin-Like Growth Factor-I (IGF-I) 및 IGF Binding Protein (IGFBP)의 역할

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Type
Academic journal
Author
Cho, Chul-Ho (인하대학교 의과대학 내과학교실) Kim, Se-Kyu (연세대학교 의과대학 내과학교실) Kwak, Seung-Min (인하대학교 의과대학 내과학교실) Chang, Joon (연세대학교 의과대학 내과학교실) Kim, Sung-Kyu (연세대학교 의과대학 내과학교실) Chung, Kyung-Young (연세대학교 의과대학 흉부외과학 교실)
Journal
The Korean Academy of Tuberculosis and Respiratory Diseases Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제50권 제5호 KCI Accredited Journals SCOPUS
Published
2001.1
Pages
549 - 556 (8page)

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The Role of Insulin-like Growth Factor I(IGF-I), and IGF Binding Protein (IGFBP) in Mouse Lung Cancer Cells
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Background : IGF-I is an important mitogen in many types of malignancies. Tumors also express many IGF binding proteins, which modulate IGF action. The propose of this study was to evaluate the effect of IGF-I and IGFBP on cell proliferation in mouse lung cancer cells (3LL). Methods : The cellular proliferation of 3LL with the treatment of growth factors was evaluated using MTT assay. Western ligand blot was performed in order to determine whether 3LL cells secrete IGFBPs and we evaluated the effect of IGFBP on cellular proliferation. Results : The treatment of 3LL cells with IGF-I increased cellular proliferation in a serum free media. Western ligand blot of conditioned medium of 3LL with $^{125}I$-IGF-I demonstrated one single major band with an estimated molecular mass of 24 kDa. This band was identified as IGFBP-4 with immunoblot analysis using antisera. The addition of anti-IGFBP-4 antibody to abrogate the effect of IGFBP-4 resulted in increased cellular proliferation suggesting that IGFBP-4 inhibits cell growth. Conclusion : IGF-I increases cellular proliferation, however the secreted IGFBP-4 has an inhibitory function on cell growth in 3LL. These findings suggest that IGF-I and IGFBP are involved in the cell proliferation.
#Insulin-like growth factor-I #lGF-I) #IGF-binding protein #IGFBP) #Cell proliferation

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