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The pharmacological properties of ginseng are mainly attributed to ginsenosides, the active constituents that are found in the extracts of different species of ginseng. Lately; the studies on ginsenosides are mainly focused on IH-901, a major intestinal bacterial metabolite of ginsenosides. In this study; we examined the anti-diabetic activity of IH-901 in C57BU61 db/db mice model. IH-901 was administrated orally at a dose of 20 mg/kg for 5 weeks. During the experimental period, body weight and blood glucose levels were measured every week. After 5 weeks, db/db mice were sacrificed and diabetic parameters were analyzed. IH-901 treated group showed a significant decrease in fasting blood glucose levels (from 10.5 mM to 9.4 mM), insulin resistance index (from 163.6 to 100.2) and triglyceride levels (from 115.3 to 70.1) compared to the diabetic control. In Pancreatic islets morphology; IH-901 treated group revealed much less infltrated mononuclear cells, indicating that IH-901 recovered ${\beta}$-cell damage due to hyperglycemia. In addition, IH-901 upregulated expressions of glucose transporter 4 (GLUT4) and PPAR-${\gamma}$ in skeletal muscle and adipose tissue, respectively. Taken together IH-901might be a potential anti-hyperglycemic agent with insulin sensitizing effect.
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The Anti-Inflammatory Effect of IH-901 in HT-29 Cells
Molecular & cellular toxicology
2007 .01
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In vitro antioxidant properties of a ginseng intestinal metabolite IH-901
Laboratory Animal Research
2011 .09
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Streptozotocin 유발 당뇨 흰쥐에서 백삼 에탄올엑스와 IH-901의 항당뇨 작용 비교
약학회지
2003 .01
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A Study on the Anti-metastatic activities and Toxicity of IH-901
대한약학회 학술대회
2000 .01
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Kinetic Analysis of the Hepatic Uptake and Biliary Excretion of IH-901. a Potential Anticancer Agents. in Rats
대한약학회 학술대회
2002 .01
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General Pharmacology of IH-901
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2003 .01
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In vitro antioxidant properties of ginseng intestinal metabolite (IH901)
한국실험동물학회 학술발표대회 논문집
2008 .11
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Comparative Analysis of the Extracellular Matrix Composition in Proliferating and Involuted Infantile Hemangiomas
Archives of plastic surgery : APS
2015 .01
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Role of the Fas/Fas Ligand Death Receptor Pathway in Ginseng Saponin Metabolite-Induced Apoptosis in HepG2 Cells
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
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An Enzyme-linked Immunosorbent for IH-901, an Active Metabolite of Ginsenoside Rb1
대한약학회 학술대회
2000 .01
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Cytotoxicity of Compound K (IH-901) and Ginsenoside Rh2, Main Biotransformants of Ginseng Saponins by Bifidobacteria, against Some Tumor Cells
Journal of Ginseng Research
2003 .09
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Comparisons of antidiabetic activity between ethanol extract of white ginseng root and IH901 in streptozotocin-induced diabetic rats
대한약학회 학술대회
2002 .01
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Radical Scavenging and Reducing Properties of IH901, Ginseng Intestinal Metabolite
한국실험동물학회 학술발표대회 논문집
2009 .04
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긴삼의 db/db 마우스에서 항당뇨 효과
약학회지
2006 .01
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A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage
대한약학회 학술대회
2003 .01
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Antitumor and Cardioprotective Effects of a Ginseng Intestinal Metabolite in Combination with Doxorubicin in Sarcoma-180 Tumor-bearing Mice
Laboratory Animal Research
2004 .12
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Interaction of IH901 and Physical Stress on Antioxidant Defense System in Skeletal Muscle and Lung Tissue of Rat
한국실험동물학회 학술발표대회 논문집
2009 .04
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Establishment of an ELISA for the Determination of IH-901 Using the Antibody against Ginsenoside Re-Bovine Serum Albumin conjugate
대한약학회 학술대회
2001 .01
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