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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 227 - 234 (8page)
이용수
이 논문의 연구 히스토리 (4)
2008
In vivo antioxidant effects of ginseng intestinal metabolite (IH901) in endurance exercise-induced oxidative stress rat model
Nam-Jin Lee
,
Yu-Ri Jung
,
Chun Mei Lin
외 2명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
In vitro antioxidant properties of ginseng intestinal metabolite (IH901)
Nam-Jin Lee
,
Yu-Ri Jung
,
Chun Mei Lin
외 2명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
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초록· 키워드
오류제보하기
IH-901 (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol or compound K) is a final intestinal bacterial metabolite of ginseng in humans. It has various pharmacologic effects such as antiaging, immunopotentiation, antistress, and antimetastatic activities. We analyzed the antioxidant activities of IH-901 using several assays including: total antioxidant activity, reductive potential, 1,1-diphenyl-2-picryl-hydrazyl, hydroxyl, superoxide and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays, a nitric oxide scavenging assay and a lipid peroxidation assay. At concentrations of 25 and 100 μg/mL, IH-901 inhibited lipid peroxidation of a linoleic acid emulsion with a potency comparable to ascorbic acid and butylated hydroxyanisole. The reductive potential of IH-901 increased in a concentrationdependent manner. IH-901 exhibited strong DPPH, hydroxyl, superoxide and ABTS radical scavenging activities. IH-901 was also an effective inhibitor of lipid peroxidation, although IH-901 had only a mild scavenging activity against nitric oxide. These results suggest that IH-901 may be a useful antioxidant agent against reactive oxygen species.
목차
Materials and Methods
Results and Discussion
Acknowledgment
References
참고문헌 (30)
참고문헌 신청
Aruoma O / 1998 / Free radicals, oxidative stress, and antioxidants in human health and disease / J Am Oil Chem Soc 75(22):199~212
Cerutti PA / 1991 / Oxidant stress and carcinogenesis / Eur J Clin Invest 21(1):1~5
Jung CH / 2006 / Antioxidant properties of various solvent extracts from wild ginseng leaves / LWT-FOOD SCIENCE AND TECHNOLOGY 39(3):266~274
Halliwell B / 1995 / Antioxidant characterization : Methodology and mechanism / Biochem Pharmacol 49(10):1341~1348
Jung CH / 2005 / Antioxidant activities of cultivated and wild Korean ginseng leaves / FOOD CHEMISTRY 92(3):535~540
Cerutti PA / 1991 / Oxidant stress and carcinogenesis / Eur J Clin Invest 21(1):1~5
Jung CH / 2006 / Antioxidant properties of various solvent extracts from wild ginseng leaves / LWT-FOOD SCIENCE AND TECHNOLOGY 39(3):266~274
Halliwell B / 1995 / Antioxidant characterization : Methodology and mechanism / Biochem Pharmacol 49(10):1341~1348
Jung CH / 2005 / Antioxidant activities of cultivated and wild Korean ginseng leaves / FOOD CHEMISTRY 92(3):535~540
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UCI(KEPA) : I410-ECN-0101-2013-510-000764465