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논문 기본 정보

자료유형
학술저널
저자정보
홍성우 (전북대학교 치과대학 구강악안면방사선학교실 및 구강생체과학연구소) 최은숙 (전북대학교 치과대학 구강악안면방사선학교실 및 구강생체과학연구소) 고광준 (전북대학교 치과대학 구강악안면방사선학교실 및 구강생체과학연구소)
저널정보
대한영상치의학회 치과방사선 치과방사선 제29권 제1호
발행연도
1999.1
수록면
327 - 339 (13page)

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Objectives: The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. Material and Methods: Human epidermoid carcinoma A-431 cell lines were irradiated by 2, 4, 6, 8, 10Gy at a dose rate of 210cGy/min using <SUP>60</SUP>Co Irradiator ALDORADO 8 and then were exposed to bleomycin or cisplatin at concentration of 2&#13197;/&#13206; for 1 hour. The viable cells were determined for each radiation dose and/or each drug at the 4th day and cell surviving curves were obtained using semiautomated MTT assay. Results: The surviving fraction after irradiation of 2Gy was 0.99, and there was not significant difference of surviving fraction in comparison with the control group on A-431 cell line(P&gt;0.05). But there were significant differences of surviving fractions at doses of 4, 6, 8, 10Gy in comparison with the control group(P&lt;0.05). The cytotoxicity of bleomycin or cisplatin was significantly different in comparison with the control group on A-43l cell line (P&lt;0.05). And the cytotoxicity of cisplatin was greater than that of bleomycin on A-431 cell line (P&lt;0.05). There were significant differences of surviving fractions after irradiation of 2, 4, 6, 8, 10Gy with bleomycin or cisplatin in comparison with each group of irradiation only on A-431 cellline(P&lt;0.05). There were significant differences of surviving fractions between the groups of irradiation with bleomycin and cisplatin at doses of 2, 4Gy(P&lt;0.05), but there were not significant differences of surviving fractions at doses of 6, 8, 10Gy on A-431 cell line (P&gt;0.05).

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