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논문 기본 정보

자료유형
학술저널
저자정보
이언경 (전북대학교 치과대학 구강악안면방사선학 교실) 고광준 (전북대학교 치과대학 구강악안면방사선학 교실)
저널정보
대한영상치의학회 치과방사선 치과방사선 제26권 제2호
발행연도
1996.1
수록면
121 - 132 (12page)

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The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. For this study, cell surviving curves were obtained for human osteosarcoma MG-63 cell line using semiautomated MTT assay. 2,4, 6, 8, 10Gy were irradiated at a dose rate of 210cGy/min using <SUP>60</SUP>Co Irradiator ALDORADO 8. After irradiation, MG-63 cell lines(3&times;10&#8308; cells/ml) were exposed to bleomycin and cisplatin at concentration of 0.2, 2, 20&#13197;/&#13206; for 1 hour respectively. The viable cells were determined for each radiation dose and/or each concentration of drug. And they were compared to control values. The obtained results were as follows : 1. There was significant difference of surviving fraction at 4, 6, 8, 10Gy on MG-63 cell line(p&lt;0.05). 2. There was significant difference of cytotoxicity of bleomycin or cisplatin at all concentration of 0.2, 2, 20&#13197;/&#13206; (p&lt;0.05) on MG-63 cell line. The cytotoxicity of cisplatin was more effective than bleomycin at concentration of 20&#13197;/&#13206; on MG-63 cell line. 3. There was significant difference of cytotoxicity of bleomycin or cisplatin at all concentration after irradiation of 2Gy on MG-63 cell line. 4. There was significant difference of cytotoxicity of bloemycin or cisplatin at concentration of 20&#13197;/&#13206; after irradiation than that of irradiation alone(p&lt;0.01). But there was no significant difference of cytotoxicity of bleomycin at concentration of 20&#13197;/&#13206; after irradiation of l0Gy than that of irradiation alone.

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