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논문 기본 정보

자료유형
학술저널
저자정보
장규태 (경상대학교 축산진흥연구소) 김성현 (경상대학교 축산진흥연구소) 성환후 (축산기술연구소) 주학진 (경상대학교 축산진흥연구소) 박미령 (경상대학교 축산진흥연구소) 윤창현 (경상대학교 축산진흥연구소)
저널정보
한국동물번식학회 한국동물번식학회지 한국동물번식학회지 제22권 제2호
발행연도
1998.1
수록면
137 - 143 (7page)

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The effects of continuous GH(hGH) secretion on the female reproduction was studies in adults female transgenic rats expressing the hGH gene with a mouse whey acid protein (mWAP) promotor. Two line of transgenic female rats carrying the mWAP/hGH gene were established and used in the study. One was characterized by relatively high levels of serum hGH (high line), and the other had relatively low levels (low line). 1. High line female rats had recurring, Pseudopregancy-like estrous cycles accompanied by increased serum progesterone level for 2 weeks after ovulation, and they were fertile. 2. In the rats, luteinization occurred spontaneously without cervical stimulation, probably due to high levels of serum hGH, which has prolactin (PRL)-like activity in the rat. 3. Low line female rats had recurring, regular 4-days estrous PRL surge following cervical stimulation were not, detected and PRL secretion was not induced by a dopamine antagonist. 4. The ovarian tissue in this line had a much higher number of corpora lutea and grew much heavier than in normal littermates, suggesting impairment of PRL induced structural luteolized. Su, pp.ession of PRL secretion in the low line rats was, at least in part, due to a marked decrease in the number of lactotrophs in the pituitary. The present study shows that the serum hGH level plays a crucial role in regulating luteal function in female transgenic rats expressing the hGH gene.

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