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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 저널정보
- 한국응용약물학회 한국응용약물학회 추계학술발표논문집 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
- 발행연도
- 2003.1
- 수록면
- 65 - 65 (1page)
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초록· 키워드
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The aim of this study was to investigate the effect of resveratrol on the oxidative stress-induced inhibition of gap junctional intercellular communication (GJIC) in HaCaT keratinocyte. Anti-oxidative activity of resveratrol was measured by a,a-diphenyl-b-picrylhydrazyl (DPPH) assay and dichlorodihydrofluorescein diacetate oxidation assay. GJIC of HaCaT keratinocyte was assessed using the scrape loading/dye transfer technique. Western blots and reverse transcription-polymerase chain reaction were also analyzed for Connexin 43 protein and mRNA expression, respectively. Resveratrol scavenged directly the stable DPPH radical over a concentration range of 4 mg/$\mell$ (78.2 $\pm$ 2.7% of control) to 500 mg/$\mell$ (29.9 $\pm$ 4.2% of control) and prevent to increase the intracellular fluorescence induced by oxidative stress significantly. Ultraviolet A irradiation (UVA) and 12-O-tetradecanoylphorbol-13-acetate markedly reduced GJIC, which was restored by resveratrol. There were no significant differences in the level of Connexin 43 protein and mRNA expression among any of the experimental groups. Our data suggests that resveratrol has the protective effect on the oxidative stress-induced inhibition of gap junctional intercellular communication in HaCaT keratinocyte and this protection is likely due to the scavenging of reactive oxygen species.
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Protective Effect of Resveratrol on the Oxidative Stress-Induced Inhibition of Gap Junctional Intercellular Communication in HaCaT Keratinocytes
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In Vivo Gap Junctional Intercellular Communication Assay for Short-term Model of Tumorigenesis
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6'-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage
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포공영 추출물의 항산화 효과 및 피부 각질세포 보호효과
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2009 .01
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발암물질 H₂O₂의 Connexin 발현 억제에 대한 녹차 추출물의 예방효과
대한이비인후-두경부외과학회지
2008 .01
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Differential Expressions of Gap Junction Proteins during Differentiation of Rat Neuronal Stem Cells
한국환경성돌연변이·발암원학회지
2003 .03
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Inhibitory Effect of Bisphenol A on Gap Junctional Intercellular Communication in an Epithelial Cell line of Rat Mammary Tissue
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
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Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver
Asian Pacific journal of cancer prevention : APJCP
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Synergistic effect of maclurin on ginsenoside compound K induced inhibition of the transcriptional expression of matrix metalloproteinase-1 in HaCaT human keratinocyte cells
Journal of Ginseng Research
2018 .04
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2017 .01
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Propolis Inhibits UVA-Induced Apoptosis of Human Keratinocyte HaCaT Cells by Scavenging ROS
Toxicological Research
2016 .10
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Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
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