지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제30권 제3호
- 발행연도
- 2007.1
- 수록면
- 337 - 343 (7page)
이용수
초록· 키워드
오류제보하기
An endocrine disruptor, bisphenol-A (BPA), has been reported to have several short-term actions in various cells and tissues. However, the mechanisms of these actions have not been fully elucidated. In order to assess the effect of BPA on the intercellular communication modiated by gap junctions, we conducted the present study in the rat epithelium-derived BICR-M1Rk cell-line, in which connexin 43 (Cx43) is a major gap junction channel-forming protein. The cytotoxicity of BPA toward the cultured cells was evaluated by using both MTT reduction and LDH leakage assay systems. The results showed no appreciable loss in cell viability in the presence of increasing concentrations of BPA (from 0.1 to 3.2 ${\mu}$M) for 1 h incubation. However, most of cell viability was lost when cells were incubated for 24 hr with the same concen-trations of BPA. The BPA acted as an antagonist on gap junction-mediated intercellular communication (GJIC), and the phenomenon was dose-dependent and irreversible. Accord-ing to the data obtained from scrape-leading dye-transfer experiments, three quarters of nor-mal GJIC was reduced by concentration of 0.4 ${\mu}$M BPA for 1 h incubation. To identify there levance of this retardation upon BPA treatment, the GJIC to Cx43 synthesis, the mRNA and protein levels of Cx43 were assessed with RT-PCR and Western-blotting, respectively. The total protein level of Cx43 was almost constant in a wide range of BPA concentrations, as wel las in Cx43 mRNA level. These results suggest that BPA inhibits GJIC through a modulation of the gating of gap junction channels, not through a genomic modulation of Cx43.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
발암물질 H₂O₂의 Connexin 발현 억제에 대한 녹차 추출물의 예방효과
대한이비인후-두경부외과학회지
2008 .01
-
Differential Expressions of Gap Junction Proteins during Differentiation of Rat Neuronal Stem Cells
한국환경성돌연변이·발암원학회지
2003 .03
-
임신중인 생쥐에 Bisphenol A 투여 후 태어난 차산자의 생식독성과 혈액성분에 관한 연구
Toxicological Research
2005 .06
-
Serum Bisphenol A Concentration in Postmenopausal Women with Osteoporosis
대한골대사학회지
2012 .01
-
정수처리공정에서 Bisphenol-A의 제거에 관한 연구
한국환경보건학회지
2004 .01
-
Ginseng Saponin as an Antagonist for Gap Junctional Channels
Journal of Ginseng Research
2006 .06
-
한국 성인의 비스페놀 A 노출과 비만과의 관련성 연구: 제2기 국민환경보건기초조사(2012-2014)
한국환경보건학회지
2018 .01
-
PC12 and cortical neuron cell death by Bisphenol A through ERK signal pathway : role of estrogen-receptor $\beta$
대한약학회 학술대회
2003 .01
-
사람의 유방암 세포주와 미성숙 랫드에서 정향피의 비스페놀 A 독성방어 효과
Toxicological Research
2005 .03
-
아파트 건축 작업장에서 사용되는 에피클로로하이드린-비스페놀A의 노출 평가: 파일럿 연구
한국산업보건학회지
2016 .01
-
Understanding the molecular mechanisms of bisphenol A action in spermatozoa
Clinical and experimental reproductive medicine : CERM
2019 .01
-
제조업 근로자들의 Bisphenol A 노출, 대사효소 유전자다형성 및 대사산물과의 상관성
대한직업환경의학회지
2008 .06
-
사람 상피세포주(HaCaT)에서의 간극결합 세포 간 신호전달의 조절
대한이비인후-두경부외과학회지
2010 .01
-
Associations between Exposure to Bisphenol A and Behavioral and Cognitive Function in Children with Attention-deficit/Hyperactivity Disorder: A Case-control Study
Clinical Psychopharmacology and Neuroscience
2020 .01
-
BPA exposure and liver function in elderly
대한직업환경의학회 학술대회 논문집
2010 .11
-
Establishment of the Korean Tolerable Daily Intake of Bisphenol A Based on Risk Assessments by an Expert Committee
Toxicological Research
2010 .12
-
자궁근종 환자에서 측정한 혈중 bisphenol-A 농도
Obstetrics & Gynecology Science
2010 .01
-
Bisphenol A의 급성노출이 마우스의 면역기능에 미치는 영향
약학회지
2001 .01
-
Bisphenol A(BPA)에 의해 야기되는 생식세포 이상영향에 관한 연구
환경독성보건학회 심포지엄 및 학술대회
2007 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0