지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In terms of management of Paget’s disease of bone (PDB), early diagnosis and proper management achieving remission is essential with lifelong specialist follow-up. We present the case of a 40-year-old woman with PDB affecting mainly the distal extremities (ankle and wrist). The patient visited our hospital in 2012 with heel pain. Plain radiography revealed osteoporosis, and a bone scan revealed hot uptake. Initial laboratory investigations showed normal serum calcium, 25-hydroxy-vitamin D, and parathyroid hormone levels; however, osteocalcin, C-terminal telopeptide of type I collagen, and bone alkaline phosphatase levels were elevated. A bone mineral density scan showed T- and Z-scores of -2.5 and -2.7, respectively, and bisphosphonate treatment was initiated. Biopsy performed on the calcaneal lateral wall revealed inconclusive findings. Follow-up biopsy on the left distal radius was performed 7 years later to investigate wrist pain, and this examination led to a final diagnosis as PDB. We suggest inconclusive biopsy result during the early phase of PDB and highly recommend follow-up evaluation in osteoporosis with atypical behavior.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Paul Tuck S / 2017 / Adult Paget’s disease of bone: a review / Rheumatology (Oxford) 56:2050~2059
Sankaran S / 2012 / Paget's disease in patients of Asian descent in New Zealand / J Bone Miner Res 27:223~226
Brandi ML / 2010 / Current treatment approaches for Paget’s Disease of Bone / Discov Med 10:209~212
Singer FR / 2014 / Paget’s disease of bone : an endocrine society clinical practice guideline / J Clin Endocrinol Metab 99:4408~4422
Wat WZ / 2014 / Current perspectives on bisphosphonate treatment in Paget’s disease of bone / Ther Clin Risk Manag 10:977~983
Sankaran S / 2012 / Paget's disease in patients of Asian descent in New Zealand / J Bone Miner Res 27:223~226
Brandi ML / 2010 / Current treatment approaches for Paget’s Disease of Bone / Discov Med 10:209~212
Singer FR / 2014 / Paget’s disease of bone : an endocrine society clinical practice guideline / J Clin Endocrinol Metab 99:4408~4422
Wat WZ / 2014 / Current perspectives on bisphosphonate treatment in Paget’s disease of bone / Ther Clin Risk Manag 10:977~983
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