지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Paget’s disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget’s disease is rare in Asian descendants. We report the cases of Paget’s disease who visited our institute for 15 years and reviewed the literatures. Methods: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget’s disease of bone. Diagnosis was confirmed by typical radiological feature in the involved skeletons and/or pathologic findings. Results: Pelvis, skull and spine were three most frequently involved bones. All involved bones in our cases showed changes in shape and trabecular pattern which resulted in bowing of lower extremity, secondary osteoarthritis, compression fracture of spine and enlargement of skull. Mean follow time was 4.71 years and all patient were treated bisphosphonate (BP). Use of BP controlled the level of serum alkaline phosphatase level effectively. Conclusions: We have reviewed eight patients who were previously diagnosed as Paget’s disease of bone in our institute. We could identify typical radiologic and clinical findings such as bowing deformity of long bone, secondary osteoarthritis, compression fracture and osteomyelitis of mandible that deteriorated the quality of their living.
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참고문헌 (18)
참고문헌 신청
Bhargava P / 2010 / Images in clinical medicine. "Cotton wool" appearance of Paget’s disease / N Engl J Med 363 : e9 ~
Cho JW / 2017 / Healing of atypical subtrochanteric femur fractures after cephalomedullary nailing: which factors predict union? / J Orthop Trauma 31 : 138 ~ 145
Deborah L. Galson / 2014 / Pathobiology of Paget’s Disease of Bone / 대한골대사학회지 21 (2) : 85 ~ 97
Khosla S / 2007 / Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research / J Bone Miner Res 22 : 147
Koh JS / 2010 / Femoral cortical stress lesions in long-term bisphosphonate therapy: a herald of impending fracture? / J Orthop Trauma 24 : 75 ~ 81
Cho JW / 2017 / Healing of atypical subtrochanteric femur fractures after cephalomedullary nailing: which factors predict union? / J Orthop Trauma 31 : 138 ~ 145
Deborah L. Galson / 2014 / Pathobiology of Paget’s Disease of Bone / 대한골대사학회지 21 (2) : 85 ~ 97
Khosla S / 2007 / Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research / J Bone Miner Res 22 : 147
Koh JS / 2010 / Femoral cortical stress lesions in long-term bisphosphonate therapy: a herald of impending fracture? / J Orthop Trauma 24 : 75 ~ 81
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