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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Hizikia fusiforme, a brown algae, is a major polysaccharide composed of alginate and fucoidan. In this study, the extraction of the useful substance using the organic solvent is generally avoided and a simple biocompatible / eco-friendly extraction method is devised to obtain an extract containing the water-soluble polymer polysaccharide as the main component from the dried or raw Hizikia fusiforme. In this study, the water soluble polymer polysaccharides were prepared with enzyme digestion and recovered with ethanol precipitation. The changes of reducing sugar content and protein content were observed and the molecular weight distribution was analyzed after enzyme digestion. Molecular weight measurements were performed using HPAEC and HPLC to reveal the constituents of the fraction material having anti-obesity bioactivity. The molecular weight (MW) of the extract was analyzed using a RI (Refractive Index) detector using a GPC column (PSS Suprema 1,000Å). Dextran (MW: 5, 12, 50, 150, 670 kDa) was used as a standard. As a result, polysaccharides composed of fucose, galactose and xylose (Average molecular weight: 18.5 kD) were identified. The IC50 value was determined using an enzyme extract having the best inhibition rate in the anti-obesity activity inhibition experiment. viscozyme, celluclast and alcalse were 14.06, 11.27, and 10.02 mg/ml, respectively, indicating that alcalase is most suitable.
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참고문헌 (22)
참고문헌 신청
Kolsi, R. B. A. / 2017 / International Journal of Biological Macromolecules 102:119~129
Jeongmin Lee / 2016 / Effect of Hijikia fusiforme extracts on degenerative osteoarthritis in vitro and in vivo models / Nutrition Research and Practice 10(3):265~273
Kwon, T. H. / 2015 / Journal of the Science of Food and Agriculture 95(9):1830~1837
Castro, M. / 2016 / Current Topics in Medicinal Chemistry 16(23):2577~2604
Ding, Y. / 2019 / Marine Drugs 17(11):637
Jeongmin Lee / 2016 / Effect of Hijikia fusiforme extracts on degenerative osteoarthritis in vitro and in vivo models / Nutrition Research and Practice 10(3):265~273
Kwon, T. H. / 2015 / Journal of the Science of Food and Agriculture 95(9):1830~1837
Castro, M. / 2016 / Current Topics in Medicinal Chemistry 16(23):2577~2604
Ding, Y. / 2019 / Marine Drugs 17(11):637
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