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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제3호
- 발행연도
- 2021.1
- 수록면
- 281 - 296 (16page)
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초록· 키워드
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Background At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic. Area covered Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARSCoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti- SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of different therapeutic strategies are summarized. According to the WHO, different classes of drugs can be used, including anti-malarial, antiviral, anti-inflammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2. Expert opinion A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.
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참고문헌 (108)
참고문헌 신청
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Amici C / 2006 / Indomethacin has a potent antiviral activity against SARS coronavirus / Antivir Ther 11:1021~1030
Andreone P / 2001 / Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial / Antiviral Res 49:75~81
Balzarini J / 2006 / Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics / Antiviral Res 72:20~33
Balzarini J / 2003 / Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics / J Med Chem 46:2755~2764
Amici C / 2006 / Indomethacin has a potent antiviral activity against SARS coronavirus / Antivir Ther 11:1021~1030
Andreone P / 2001 / Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial / Antiviral Res 49:75~81
Balzarini J / 2006 / Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics / Antiviral Res 72:20~33
Balzarini J / 2003 / Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics / J Med Chem 46:2755~2764
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