Predictors of early recurrence following a curative resection in patients with a carcinoma of the ampulla of Vater

Chung Hyeun Ma; Jae Hoon Lee; Ki Byung Song; Dae Wook Hwang; Song Cheol Kim

추천

검색

질문

자료유형: 학술저널

저자정보: Chung Hyeun Ma (University of Ulsan College of Medicine) Jae Hoon Lee (University of Ulsan College of Medicine) Ki Byung Song (University of Ulsan College of Medicine) Dae Wook Hwang (University of Ulsan College of Medicine) Song Cheol Kim (University of Ulsan College of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.5

발행연도: 2020.11

수록면: 259 - 267 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Ampulla of Vater (AoV) carcinoma has a relatively good prognosis. The 5-year recurrence rate for AoV is still around 40%-50% however, and most recurrences occur in the early period. The aim of this study was to identify predictors of an early recurrence in AoV patients following a curative resection.
Methods: The clinicopathological data for 501 consecutive patients that underwent a resection for AoV in our institute between January 2000 and December 2015 were retrospectively reviewed. The characteristics of any recurrences and early recurrence patients were analyzed accordingly. Early recurrence was defined as occurring within one year of resection.
Results: There were 170 diagnosed recurrences in our study population, 57.1% of whom were men, with a mean age of 60.1 years (range, 30–94 years). Almost all of the study patients underwent a pancreaticoduodenectomy, and 9% underwent minimally invasive surgery. Of the 170 recurrent cases, 107 were diagnosed with an early recurrence and had 1-, 3-, and 5-year overall survival rates of 77.7%, 18.4%, 10.5%, respectively. The factors that significantly influenced early recurrences, determined by multivariate analysis, lymphovascular invasion (LVI), lymph node ratio (LNR), and poor differentiation were found to be independent determinants of a recurrence within 1 year.
Conclusion: An early recurrence in AoV patients is ultimately lethal even though this cancer has a good prognosis. LVI, LNR, and poor differentiation are powerful predictors of an early recurrence in AoV. Hence, intensive surveillance and new therapeutic strategies should be considered for AoV patients with these predictors following a curative resection.

#Ampulla of Vater #Early recurrence #Pancreaticoduodenectomy #Periampullary cancer

참고문헌 (30)

참고문헌 신청

Bucher P / 2007 / Long-term results of surgical treatment of Vater’s ampulla neoplasms / Hepatogastroenterology 54:1239~1242

Park JS / 2007 / Factors influencing recurrence after curative resection for ampulla of Vater carcinoma / J Surg Oncol 95:286~290

Bhatia S / 2006 / Adjuvant therapy for ampullary carcinomas : the Mayo Clinic experience / Int J Radiat Oncol Biol Phys 66:514~519

Todoroki T / 2003 / Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater / Ann Surg Oncol 10:1176~1183

Beger HG / 1999 / Tumor of the ampulla of Vater : experience with local or radical resection in 171consecutively treated patients / Arch Surg 134:526~532

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!