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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 학술저널
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- 발행연도
- 2020.1
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Immunoglobulin (Ig)A vasculitis nephritis (IgAVN), also referred to as Henoch- Schönlein purpura nephritis, is a relatively benign disease in children. However, two 24-year European cohort studies have reported high sustained rates of hypertension, severe proteinuria, and renal dysfunction in patients with IgAVN. Notably, the incidence and exacerbation rates of proteinuria, hypertension, and renal dysfunction during pregnancy were high even in women who recovered from IgAVN before pregnancy. Patients with IgAVN need lifelong care. Trials have been performed to investigate early biomarkers and genes associated with poor prognosis to identify high-risk patients in whom IgAVN may progress to severe renal disease. Urinary IgA/cr, IgM/cr levels, and HLAB35 and angiotensinogen gene expression were shown to be predictors of progression of IgAVN to severe renal dysfunction. The 2019 Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative group published guidelines for pediatric IgAVN, following the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines established in 2012. Compared with the KDIGO guidelines, the SHARE guidelines recommend earlier corticosteroid administration in cases of mild proteinuria (>0.5 g/d). Clinical trials of targeted budesonide delivery to the distal ileum, monoclonal antibody targeting C5, eculizumab and anti-CD20 monoclonal antibody administration, among others are currently underway in patients with IgA nephropathy. It is expected that newer therapeutic agents would become available for IgAVN in the near future. This review summarizes IgAVN with emphasis on recently published literature, including possible preventive strategies, predictive biomarkers for progression of IgAVN, and various treatments.
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참고문헌 (82)
참고문헌 신청
Pillebout E / 2017 / Biomarkers of IgA vasculitis nephritis in children / PLoS One 12:e0188718
Jennette JC / 2013 / 2012 Revised International Chapel Hill consensus conference nomenclature of Vasculitis / Arthritis Rheum 65:1~11
Mills JA / 1990 / The American College of Rheumatology 1990 criteria for the classification of vasculitis / Arthritis Rheum 33:1114~1121
Ozen S / 2010 / EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria / Ann Rheum Dis 69:798~806
정도영 / 2017 / Clinical Features and Prognosis of Henoch-Schönlein Purpura in Children and Adults: A 13-Year Retrospective Study at a Single Centre / Childhood Kidney Diseases 21(2):61~68
Jennette JC / 2013 / 2012 Revised International Chapel Hill consensus conference nomenclature of Vasculitis / Arthritis Rheum 65:1~11
Mills JA / 1990 / The American College of Rheumatology 1990 criteria for the classification of vasculitis / Arthritis Rheum 33:1114~1121
Ozen S / 2010 / EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria / Ann Rheum Dis 69:798~806
정도영 / 2017 / Clinical Features and Prognosis of Henoch-Schönlein Purpura in Children and Adults: A 13-Year Retrospective Study at a Single Centre / Childhood Kidney Diseases 21(2):61~68
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