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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 98 - 104 (7page)
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초록· 키워드
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Thalassemias are considered important health issues throughout Iraq, involving its Kurdistan region. This disorder, particularly its major form, needs lifelong regular transfusions. But this form of medical care is associated with various complications including red cell alloimmunization and autoim-munization. This study determined the frequency and associations of alloimmunization among multi-transfused patients with β-thalassemia major. The subjects were 204 patients who were registered at a thalassemia care center in Sulaymaniyah-Iraqi Kurdistan. The patients’ records were analyzed, their red cells were phenotyped for ABO/RhD antigens using the gel card method, and irregular antibody screening/identification was performed using the standard tube method. Alloantibodies were detected in 5.8% of the patients, while DAT was positive in 4% of the patients, which indicated autoantibodies. The identified alloantibodies were anti-E (2.4%), anti-C (1.4%), anti-e (1%), and anti-K (1%). A patient’s age at the start of transfusion (＞2 years) (P=0.042) and a positive history of transfusion reactions (P=0.003) were correlated with a significantly higher rate of alloantibody formation. From the results of our study, we conclude that measures to decrease the development of alloantibodies may incorporate matching for Rhesus and Kell systems and early induction of blood transfusions.
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참고문헌 (28)
참고문헌 신청
DAVID J. WEATHERALL / 1995 / The Molecular Basis for Phenotypic Diversity of Genetic Disease / Annals of the New York Academy of Sciences 758(1 DNA):245~260
Iheanyi EO / 2004 / Practical management of haemoglobinopathies / Blackwell publishing
Hanan A. Hamamy / 2013 / Epidemiological profile of common haemoglobinopathies in Arab countries / Journal of Community Genetics 4(2):147~167
Anchalee Thedsawad / 2019 / Prevalence and clinical significances of red cell alloimmunization and red cell bound immunoglobulin G in polytransfused patients with thalassemias / Hematology 24(1):208~214
Cappellini MD / 2014 / Guidelines for the management of transfusion dependent thalassaemia (TDT) / Thalassaemia International Federation
Iheanyi EO / 2004 / Practical management of haemoglobinopathies / Blackwell publishing
Hanan A. Hamamy / 2013 / Epidemiological profile of common haemoglobinopathies in Arab countries / Journal of Community Genetics 4(2):147~167
Anchalee Thedsawad / 2019 / Prevalence and clinical significances of red cell alloimmunization and red cell bound immunoglobulin G in polytransfused patients with thalassemias / Hematology 24(1):208~214
Cappellini MD / 2014 / Guidelines for the management of transfusion dependent thalassaemia (TDT) / Thalassaemia International Federation
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