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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 569 - 573 (5page)
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초록· 키워드
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Brucellosis is a zoonotic disease caused by Brucella infections and humans usually contract this disease from close contact with infected animals or their products, usually via the ingestion of cheese or crude milk. Macrophage migration inhibitory factor (MIF) and Pro- and anti-inflammatory cytokines play an important role in susceptibility/resistance and the immunopathogenesis of Brucella infection. These cytokines are crucial factors in the initiation and progression of protective immunity against Brucella infection but the role of MIF has not been well studied in the human response to intracellular microbes. This study was designed to investigate the effect of MIF expression on Brucella susceptibility. A total of 85 positive rose Bengal tests and 24 samples from healthy individuals were collected for this study and subjected to polymerase chain reaction assays (PCR) of the bcsp31 diagnostic gene. MIF concentrations were evaluated using Enzyme-Linked immunosorbent assay (ELISA) and the results showed that 46 (54%) of the rose Bengal test samples were positive and 39 (46%) were negative for bcsp31 (p ≤ 0.05) and used as the gold standard for all of the comparisons in this study. The ELISA results indicate that the mean concentration of MIF was significantly higher in patients with positive rose Bengal tests when compared to the control groups and that its concentration increases with increasing age in both the patient and control groups (p ≤ 0.05).
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참고문헌 (29)
참고문헌 신청
Franco MP / 2007 / Human brucellosis / Lancet Infect. Dis 7:775~786
Jihan S / 2007 / Incidence of brucellosis in Kirkuk Province using simple dilution microagglutination rose Bengal test method / Med. J. Tikrit 1:70~74
Tsolis RM / 2002 / Comparative genome analysis of the α-proteobacteria : relationships between plant and animal pathogens and host specificity / Proc. Natl. Acad. Sci. USA 99:12503~12505
Xavier M / 2009 / Pathological, immunohistochemical and bacteriological study of tissues and milk of cows and fetuses experimentally infected with Brucella abortus / J. Comp. Pathol 140:149~157
Poester F / 2013 / Pathogenesis and pathobiology of brucellosis in livestock / Rev. Sci. Tech 32:105~115
Jihan S / 2007 / Incidence of brucellosis in Kirkuk Province using simple dilution microagglutination rose Bengal test method / Med. J. Tikrit 1:70~74
Tsolis RM / 2002 / Comparative genome analysis of the α-proteobacteria : relationships between plant and animal pathogens and host specificity / Proc. Natl. Acad. Sci. USA 99:12503~12505
Xavier M / 2009 / Pathological, immunohistochemical and bacteriological study of tissues and milk of cows and fetuses experimentally infected with Brucella abortus / J. Comp. Pathol 140:149~157
Poester F / 2013 / Pathogenesis and pathobiology of brucellosis in livestock / Rev. Sci. Tech 32:105~115
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