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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제2호
- 발행연도
- 2020.1
- 수록면
- 189 - 200 (12page)
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초록· 키워드
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Purpose The aim of the present study was to prepare gelatin nanoparticles (GNPs) using modified one step desolvation method to obtain small, uniformly sized, and spherical GNPs. Methods The modifications involved the preparation of high molecular weight gelatin (HMWG) by fractionation of gelatin. HMWG was freeze-dried to be used in a specified concentration for preparation of GNPs with controllable properties. Furthermore, HMWG was cationized by dissolving it in acidified deionized water at pH value less than its isoelectric point. Factorial design analysis was utilized to investigate the effect of different preparation variables (viz. HMWG concentration, pH and ratio of HMWG solution volume to non-solvent volume) on particle size, polydispersity index (PDI), zeta potential and yield of GNPs. Results Results revealed the formation of monodisperse GNPs with small particle size, low PDI values (< 0.2) and high yield. FT-IR spectroscopy and differential scanning calorimetry studies revealed that the conformational structure of HMWG chains was altered within GNPs matrices. Conclusion The suggested modifications introduced on the one-step desolvation method enable to prepare successfully monodispersed GNPs with narrow size distribution and high particle yield.
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참고문헌 (49)
참고문헌 신청
Ahlers M / 2008 / U.S. Patent Application No. 11/675,643
Ahsan SM / 2017 / The role of surface charge in the desolvation process of gelatin : implications in nanoparticle synthesis and modulation of drug release / Int J Nanomed 12:795~808
Azarmi S / 2006 / Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells / J Pharm Pharm Sci 9:124~132
Azimi B / 2013 / Producing gelatin nanoparticles as delivery system for bovine serum albumin / Iran Biomed J 18:34~40
Balthasar S / 2005 / Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes / Biomaterials 26:2723~2732
Ahsan SM / 2017 / The role of surface charge in the desolvation process of gelatin : implications in nanoparticle synthesis and modulation of drug release / Int J Nanomed 12:795~808
Azarmi S / 2006 / Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells / J Pharm Pharm Sci 9:124~132
Azimi B / 2013 / Producing gelatin nanoparticles as delivery system for bovine serum albumin / Iran Biomed J 18:34~40
Balthasar S / 2005 / Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes / Biomaterials 26:2723~2732
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