지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 395 - 402 (8page)
이용수
초록· 키워드
오류제보하기
Subcutaneous adipose tissue (SAT) accumulation is a constitutional disorder resulting from metabolic syndrome. Although surgical and non-surgical methods for reducing SAT exist, patients remain non-compliant because of potential adverse effects and cost. In this study, we developed a new minimally-invasive approach to achieve SAT reduction, using a microneedle (MN) patch prepared from gelatin, which is capable of regulating fat metabolism. Four gelatin types were used: three derived from fish (SA-FG, GT-FG 220, and GT-FG 250), and one from swine (SM-PG 280). We applied gelatin-based MN patches five times over 4 weeks to rats with high-fat diet (HD)-induced obesity, and determined the resulting amount of SAT. We also investigated the histological features and determined the expression levels of fat metabolism-associated genes in SAT using hematoxylin and eosin staining and western blotting, respectively. SAT decreased following treatment with all four gelatin MN patches. Smaller adipocytes were observed in the regions treated with SA-FG, GT-FG 250, and SM-PG 280 MNs, demonstrating a decline in fat accumulation. The expression levels of fat metabolism-associated genes in the MN-treated SAT revealed that GT-FG 220 regulates fatty acid synthase (FASN) protein levels. These findings suggest that gelatin MN patches aid in decreasing the quantity of unwanted SAT by altering lipid metabolism and fat deposition.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
Cheung, W.W. / 2012 / Recent advances in obesity: genetics and beyond / ISRN Endocrinol 2012:536905
Bell, J.A. / 2014 / Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies / Obes. Rev 15:504~515
Coutinho, P.M. / 2003 / An evolving hierarchical family classification for glycosyltransferases / J. Mol. Biol 328:307~317
Morigny, P. / 2016 / Adipocyte lipolysis and insulin resistance / Biochimie 125:259~266
Wajchenberg, B. L. / 2000 / Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome / Endocr. Rev 21:697~738
Bell, J.A. / 2014 / Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies / Obes. Rev 15:504~515
Coutinho, P.M. / 2003 / An evolving hierarchical family classification for glycosyltransferases / J. Mol. Biol 328:307~317
Morigny, P. / 2016 / Adipocyte lipolysis and insulin resistance / Biochimie 125:259~266
Wajchenberg, B. L. / 2000 / Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome / Endocr. Rev 21:697~738
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