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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제50권 제2호
- 발행연도
- 2020.1
- 수록면
- 201 - 208 (8page)
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Purpose Antiretroviral therapy remains the most effective means of managing the human immune deficiency virus/acquired immune deficiency syndrome (HIV/AIDS). Application of therapeutics has been hampered by factors including poor bioavailability of most anti-retroviral compounds (ARV), side effects and an alarming emergence of drug resistant strains of the virus. Methods Recent developments and use of drug delivery systems (DDS) has shown potential for improving the pharmacological profile of ARV. Amongst these complex DDS, liposomes have been explored for delivery of ARV. In this study, we have aimed at exploring efficient encapsulation of efavirenz (EFV), a potent ARV using different mass ratios of crude soybean lecithin and cholesterol. Results The EFV-loaded liposomes (EFL) were prepared using thin film hydration and evaluated for particle size, zeta potential (ZP), encapsulation efficiency (EE%), morphology and drug release studies. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), energy dispersity spectroscopy (EDS) and Fourier transform infrared (FTIR) spectroscopy were used for comprehensive physicochemical characterization of EFL. EFL exhibited high encapsulation (99%) in 1:1 crude lecithin to cholesterol mass ratio. The average particle size and Zeta Potential of EFL were found to be 411.10 ± 7.40 nm and − 53.5.3 ± 0.06 mV, respectively. EFL showed a relatively controlled EFV release behaviour that was similar to the dissolution profile of un-encapsulated EFV. Conclusion This suggests that EFL represents a promising vehicle for effective EFV delivery while providing the advantages of a nano-scaled delivery system.
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참고문헌 (35)
참고문헌 신청
Branch SK / 2005 / Guidelines from the international conference on harmonisation(ICH) / J Pharm Biomed Anal 38:798~805
Carr A / 2000 / Adverse effects of antiretroviral therapy / The Lancet 356:1423~1430
Chiappetta DA / 2010 / Efavirenz—loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significant higher oral bioavailability / Nanomedicine 5:11~23
Chowdary KPR / 2013 / Preclinical pharmacokinetic evaluation of efavirenz solid dispersions in two new modified starches / J Appl Pharm Sci 3:89~92
Chowdary KPR / 2011 / Formulation development of efavirenz tablets employing β cyclodextrin-PVP K30-SLS : a factorial study / J Appl Pharm Sci 1:130~134
Carr A / 2000 / Adverse effects of antiretroviral therapy / The Lancet 356:1423~1430
Chiappetta DA / 2010 / Efavirenz—loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significant higher oral bioavailability / Nanomedicine 5:11~23
Chowdary KPR / 2013 / Preclinical pharmacokinetic evaluation of efavirenz solid dispersions in two new modified starches / J Appl Pharm Sci 3:89~92
Chowdary KPR / 2011 / Formulation development of efavirenz tablets employing β cyclodextrin-PVP K30-SLS : a factorial study / J Appl Pharm Sci 1:130~134
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