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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 738 - 744 (7page)
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Recently, the prevalence of hyperlipidemia has been increasing, and consequently, the need to identify safe and effective treatments to control this chronic disease has also increased. The beneficial effects of probiotics have been revealed by several studies over the past few years, including their effects on hypertriglyceridemia. However, the mechanisms of action of probiotics are still unclear. The anti-obesity effects of Lactobacillus plantarum Q180 on lipid accumulation have already been demonstrated using an in vitro HepG2 cell model, and therefore, we investigated its efficacy and mechanism of action. Lipid accumulation was induced in HepG2 cells by palmitic acid treatment and then the cells were incubated with L. plantarum Q180 lysate or supernatant to investigate changes in lipid accumulation and expression of lipid metabolism-related genes. The results showed that the L. plantarum Q180-treated group exhibited significantly lower levels of lipid accumulation and mRNA expression of lipid synthesis- and adipogenesis-related genes than the palmitic acid-treated group did. These results indicate that L. plantarum Q180 may contribute to alleviating hypertriglyceridemia by inhibiting lipid synthesis.
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참고문헌 (27)
참고문헌 신청
Al-Muzafar HM / 2017 / Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and inflammatory biomarkers / BMC Complement Altern Med 17:43
Alves CC / 2017 / Prebiotic and synbiotic modifications of beta oxidation and lipogenic gene expression after experimental hypercholesterolemia in rat liver / Front Microbiol 8:2010
Ann YG / 2011 / [Lactic acid bacteria] probiotic lactic acid bacteria / Korean J Food Nutr 24:817~832
Chinetti G / 2000 / Peroxisome proliferatoractivated receptors(PPARs) : nuclear receptors at the crossroads between lipid metabolism and inflammation / Inflamm Res 49:497~505
최일동 / 2016 / Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia / Journal of Microbiology and Biotechnology 26(3):483~487
Alves CC / 2017 / Prebiotic and synbiotic modifications of beta oxidation and lipogenic gene expression after experimental hypercholesterolemia in rat liver / Front Microbiol 8:2010
Ann YG / 2011 / [Lactic acid bacteria] probiotic lactic acid bacteria / Korean J Food Nutr 24:817~832
Chinetti G / 2000 / Peroxisome proliferatoractivated receptors(PPARs) : nuclear receptors at the crossroads between lipid metabolism and inflammation / Inflamm Res 49:497~505
최일동 / 2016 / Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia / Journal of Microbiology and Biotechnology 26(3):483~487
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