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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Brucellosis is the most common zoonosis worldwide, which is caused by Brucella spp. In humans, it can be mainly occurred by direct contact with infected animals or consumption of contaminated dairy products. This study focused on human brucellosis caused by B. melitensis discovered from Chinese worker in Korea in 2015. We investigated molecular epidemiological evidence to find the infection source. We first performed several PCR methods including 16S rRNA PCR, multiplex PCR and real-time PCR to identify Brucella species. We also conducted MLVA typing for epidemiological trace-back analysis. The isolate from the patient was confirmed to B. melitensis through Brucella-specific PCR. In clustering analysis with B. melitensis from foreign countries, this human isolate was correlated with B. melitensis isolates from humans and sheep in China by 99.9% similarity. Thus, we assumed the brucellosis patient has been already infected in China followed by migration to Korea according to molecular epidemiological analysis with history evidence. Moreover, we suggest it needs to take measures to reduce the risk for intercountry transmission of brucellosis due to the influx of infected people from abroad.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Al Dahouk S / 2007 / Evaluation of Brucella MLVA typing for human brucellosis / Journal of Microbiological Methods 69:137~145
Alton GG / 1975 / Laboratory techniques in brucellosis / WHO :11~63
Bamaiyi PH / 2014 / Case-control study on risk factors associated with Brucella Melitensis in goat farms in Peninsular Malaysia / Trop Anim Health Prod 46:739~745
Godfroid J / 2002 / How to substantiate eradication of bovine brucellosis when aspecific serological reactions occur in the course of brucellosis testing / Veterinary Microbiology 90:461~477
Jiang H / 2011 / MLVA genotyping of Chinese human Brucella melitensis biovar 1, 2 and 3 isolates / BMC microbiology 11:256
Alton GG / 1975 / Laboratory techniques in brucellosis / WHO :11~63
Bamaiyi PH / 2014 / Case-control study on risk factors associated with Brucella Melitensis in goat farms in Peninsular Malaysia / Trop Anim Health Prod 46:739~745
Godfroid J / 2002 / How to substantiate eradication of bovine brucellosis when aspecific serological reactions occur in the course of brucellosis testing / Veterinary Microbiology 90:461~477
Jiang H / 2011 / MLVA genotyping of Chinese human Brucella melitensis biovar 1, 2 and 3 isolates / BMC microbiology 11:256
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몽골 유래 Brucella melitensis 동정 및 특이 SNP를 이용한 real-time PCR법에 의한 진단 평가
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2015 .06
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First Case of Human Brucellosis Caused by Brucella melitensis in Korea
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2016 .01
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A Novel PCR Assay for Detecting Brucella abortus and Brucella melitensis
Osong Public Health and Research Persptectives
2017 .01
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An Imported Case of Brucella melitensis Infection in South Korea
Infection and Chemotherapy
2018 .01
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Interaction between Brucella melitensis 16M and small ubiquitin-related modifier 1 and E2 conjugating enzyme 9 in mouse RAW264.7 macrophages
Journal of Veterinary Science
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Development and trial of vaccines against Brucella
Journal of Veterinary Science
2017 .08
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Isolation and characterization of Brucella abortus isolates from wildlife species in South Korea
Korean Journal of Veterinary Research(대한수의학회지)
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Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran
Osong Public Health and Research Persptectives
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Molecular cloning, purification and immunogenicity of recombinant Brucella abortus 544 malate dehydrogenase protein
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Nucleomodulin BspJ as an effector promotes the colonization of Brucella abortus in the host
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Evaluation of recombinant AspC of Brucella abortus for serological diagnosis of bovine brucellosis in Korea
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2015 .06
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Vaccination of goats with a combination Salmonella vector expressing four Brucella antigens (BLS, PrpA, Omp19, and SOD) confers protection against Brucella abortus infection
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2018 .09
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Pathological, immunohistochemical, and bacteriological findings in dogs infected with Brucella canis
Korean Journal of Veterinary Research(대한수의학회지)
2020 .03
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The use of real time PCR in the analysis of ancient human DNAs
대한체질인류학회 학술대회 연제 초록
2017 .06
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Effect of immunization routes and protective efficacy of Brucella antigens delivered via Salmonella vector vaccine
Journal of Veterinary Science
2018 .05
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Prevalence state of canine brucellosis in South Korea during 2015 and 2016
Korean Journal of Veterinary Research(대한수의학회지)
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The two highly immunogenic antigens of Brucella: lipopolysaccharide (LPS) and outer membrane proteins (OMPs)
예방수의학회지
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The in vitro effects of synthetic complement peptide C3a during Brucella abortus 544 infection in a murine professional phagocyte RAW264.7 cell line
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Serological monitoring and risk factors of brucellosis and Q fever in calves in Türkiye
Korean Journal of Veterinary Research(대한수의학회지)
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