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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 10 (10page)
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Objectives This study investigated the indirect effect of calcium-enriched mixture (CEM) cement and mineral trioxide aggregate (MTA), as 2 calcium silicate-based hydraulic cements, on human dental pulp stem cells (hDPSCs) through different dentin thicknesses. Materials and Methods Two-chamber setups were designed to simulate indirect pulp capping (IPC). Human molars were sectioned to obtain 0.1-, 0.3-, and 0.5-mm-thick dentin discs, which were placed between the 2 chambers to simulate an IPC procedure. Then, MTA and CEM were applied on one side of the discs, while hDPSCs were cultured on the other side. After 2 weeks of incubation, the cells were removed, and cell proliferation, morphology, and attachment to the discs were evaluated under scanning electron microscopy (SEM). Energy-dispersive X-ray (EDXA) spectroscopy was performed for elemental analysis. Alkaline phosphatase (ALP) activity was assessed quantitatively. The data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Results SEM micrographs revealed elongated cells, collagen fibers, and calcified nucleations in all samples. EDXA verified that the calcified nucleations consisted of calcium phosphate. The largest calcifications were seen in the 0.1-mm-thick dentin subgroups. There was no significant difference in ALP activity across the CEM subgroups; however, ALP activity was significantly lower in the 0.1-mm-thick dentin subgroup than in the other MTA subgroups (p < 0.05). Conclusions The employed capping biomaterials exerted biological activity on hDPSCs, as shown by cell proliferation, morphology, and attachment and calcific precipitations, through 0.1- to 0.5-mm-thick layers of dentin. In IPC, the bioactivity of these endodontic biomaterials is probably beneficial.
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참고문헌 (31)
참고문헌 신청
Thompson V / 2008 / Treatment of deep carious lesions by complete excavation or partial removal : a critical review / J Am Dent Assoc 139:705~712
Schwendicke F / 2016 / Managing carious lesions : consensus recommendations on carious tissue removal / Adv Dent Res 28:58~67
Ricketts D / 2001 / Management of the deep carious lesion and the vital pulp dentine complex / Br Dent J 191:606~610
Chogle SM / 2012 / Pulpal and periradicular response to caries : current management and regenerative options / Dent Clin North Am 56:521~536
Gruythuysen RJ / 2010 / Long-term survival of indirect pulp treatment performed in primary and permanent teeth with clinically diagnosed deep carious lesions / J Endod 36:1490~1493
Schwendicke F / 2016 / Managing carious lesions : consensus recommendations on carious tissue removal / Adv Dent Res 28:58~67
Ricketts D / 2001 / Management of the deep carious lesion and the vital pulp dentine complex / Br Dent J 191:606~610
Chogle SM / 2012 / Pulpal and periradicular response to caries : current management and regenerative options / Dent Clin North Am 56:521~536
Gruythuysen RJ / 2010 / Long-term survival of indirect pulp treatment performed in primary and permanent teeth with clinically diagnosed deep carious lesions / J Endod 36:1490~1493
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