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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 216 - 223 (8page)
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Background: Differences in the performance of suggested warfarin dosing algorithms among different ethnicities and genotypes have been reported; this necessitates the development of an algorithm with enhanced performance for specific population groups. Previous warfarin dosing algorithms underestimated warfarin doses in VKORC1 1173C carriers. We aimed to develop and validate a new warfarin dosing algorithm for Korean patients with VKORC1 1173C. Methods: A total of 109 patients carrying VKORC1 1173CT (N=105) or 1173CC (N=4) were included in this study. Multiple regression analysis was performed to deduce a new dosing algorithm. Following literature searches for genotype-guided warfarin dosing algorithms, 21 algorithms were selected and evaluated using the correlation coefficient (ρ) of actual dose and estimated dose, mean error, and root mean square error. Results: The developed algorithm is as follows: maintenance dose (mg/week)=exp [3.223−0.009×(age)+0.577×(body surface area [BSA])+0.178×(sex)−0.481×(CYP2C9 genotype)+0.227×(VKORC1 genotype)]. Integrated variables explained 44% of the variance in the maintenance dose. The predicted and actual doses showed moderate correlation (ρ=0.641) with the best performance with a mean error of -1.30 mg/week. The proportion of underestimated groups was 17%, which was lower than with the other algorithms. Conclusions: This is the first study to develop and validate a warfarin dosing algorithm based on data from VKORC1 1173C carriers; it showed superior predictive performance compared with previously published algorithms.
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참고문헌 (35)
참고문헌 신청
Shaw K / 2015 / Clinical practice recommendations on genetic testing of CYP2C9 and VKORC1 variants in warfarin therapy / Ther Drug Monit 37:428~436
김솔잎 / 2017 / Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines / Annals of Laboratory Medicine 37(2):180~193
Verhoef TI / 2014 / Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon / Br J Clin Pharmacol 77:626~641
Huang SW / 2009 / Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose : a prospective study in Chinese patients / Pharmacogenet Genomics 19:226~234
Peng Q / 2015 / Validation of warfarin pharmacogenetic algorithms in 586 Han Chinese patients / Pharmacogenomics 16:1465~1474
김솔잎 / 2017 / Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines / Annals of Laboratory Medicine 37(2):180~193
Verhoef TI / 2014 / Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon / Br J Clin Pharmacol 77:626~641
Huang SW / 2009 / Validation of VKORC1 and CYP2C9 genotypes on interindividual warfarin maintenance dose : a prospective study in Chinese patients / Pharmacogenet Genomics 19:226~234
Peng Q / 2015 / Validation of warfarin pharmacogenetic algorithms in 586 Han Chinese patients / Pharmacogenomics 16:1465~1474
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