지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제2호
- 발행연도
- 2020.1
- 수록면
- 165 - 171 (7page)
이용수
초록· 키워드
오류제보하기
Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma levels of some specialized pro-resolving mediators (SPMs, i.e., lipoxin A4 [LXA4], resolvin [Rv] E1, RvE2, RvD1 and RvD2), CD59 and interleukin (IL)-6 were measured at 0, 6, 24, 72, and 168 h after global cerebral ischemic (GCI) and traumatic brain injuries (TBI) in rats. Plasma LXA4 levels tended to increase at 24 and 72 h after GCI. Plasma RvE1, RvE2, RvD1, and RvD2 levels showed a biphasic response to GCI; a significant decrease at 6 h with a return to the levels of the sham group at 24 h, and again a decrease at 72 h. Plasma CD59 levels increased at 6 and 24 h post-GCI, and returned to basal levels at 72 h post-GCI. For TBI, plasma LXA4 levels tended to decrease, while RvE1, RvE2, RvD1, and RvD2 showed barely significant changes. Plasma IL-6 levels were significantly increased after GCI and TBI, but with different time courses. These results show that plasma LXA4, RvE1, RvE2, RvD1, RvD2, and CD59 levels display differential responses to GCI and TBI, and need to be evaluated for their usefulness as biomarkers.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Chou SH / 2014 / Monitoring biomarkers of cellular injury and death in acute brain injury / Neurocrit Care 21(Suppl 2):S187~S214
Mrozek S / 2014 / Biomarkers and acute brain injuries : interest and limits / Crit Care 18:220
Dalli J / 2015 / The regulation of proresolving lipid mediator profiles in baboon pneumonia by inhaled carbon monoxide / Am J Respir Cell Mol Biol 53:314~325
Perucci LO / 2016 / Lipoxin A4 is increased in the plasma of preeclamptic women / Am J Hypertens 29:1179~1185
Barden AE / 2016 / Specialised pro-resolving mediators of inflammation in inflammatory arthritis / Prostaglandins Leukot Essent Fatty Acids 107:24~29
Mrozek S / 2014 / Biomarkers and acute brain injuries : interest and limits / Crit Care 18:220
Dalli J / 2015 / The regulation of proresolving lipid mediator profiles in baboon pneumonia by inhaled carbon monoxide / Am J Respir Cell Mol Biol 53:314~325
Perucci LO / 2016 / Lipoxin A4 is increased in the plasma of preeclamptic women / Am J Hypertens 29:1179~1185
Barden AE / 2016 / Specialised pro-resolving mediators of inflammation in inflammatory arthritis / Prostaglandins Leukot Essent Fatty Acids 107:24~29
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