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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 53 - 68 (16page)
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The purpose of this study was to characterize the genetic contribution to endothelial adaptation to exercise training. Vasoreactivity was assessed in aortas from four inbred mouse strains (129S1, B6, NON, and SJL) after 4 weeks of moderate intensity continuous exercise training (MOD), high intensity interval training (HIT) or in sedentary controls (SED). Intrinsic variations in endothelium-dependent vasorelaxation (EDR) to acetylcholine (ACh) as well as vasocontractile responses were observed across SED groups. For responses to exercise training, there was a significant interaction between mouse strain and training intensity on EDR. Exercise training had no effect on EDR in aortas from 129S1 and B6 mice. In NON, EDR was improved in aortas from MOD and HIT compared with respective SED, accompanied by diminished responses to PE in those groups. Interestingly, EDR was impaired in aorta from SJL HIT compared with SED. The transcriptional activation of endothelial genes was also influenced by the interaction between mouse strain and training intensity. The number of genes altered by HIT was greater than MOD, and there was little overlap between genes altered by HIT and MOD. HIT was associated with gene pathways for inflammatory responses. NON MOD genes showed enrichment for vessel growth pathways. These findings indicate that exercise training has non-uniform effects on endothelial function and transcriptional activation of endothelial genes depending on the interaction between genetic background and training intensity.
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참고문헌 (58)
참고문헌 신청
Mitchell JA / 2008 / Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium / Exp Physiol 93:141~147
Delp MD / 1993 / Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta / J Appl Physiol 75:1354~1363
Kemi OJ / 2005 / Moderate vs. high exercise intensity: differential effects on aerobic fitness,cardiomyocyte contractility, and endothelial function / Cardiovasc Res 67:161~172
Higashi Y / 1999 / Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects : role of endothelium-derived nitric oxide / Circulation 100:1194~1202
Jasperse JL / 2006 / Endothelial function and exercise training : evidence from studies using animal models / Med Sci Sports Exerc 38:445~454
Delp MD / 1993 / Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta / J Appl Physiol 75:1354~1363
Kemi OJ / 2005 / Moderate vs. high exercise intensity: differential effects on aerobic fitness,cardiomyocyte contractility, and endothelial function / Cardiovasc Res 67:161~172
Higashi Y / 1999 / Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects : role of endothelium-derived nitric oxide / Circulation 100:1194~1202
Jasperse JL / 2006 / Endothelial function and exercise training : evidence from studies using animal models / Med Sci Sports Exerc 38:445~454
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